Ifosfamide Dosage

Medically reviewed by Drugs.com. Last updated on May 6, 2024.

Applies to the following strengths: 1 g; 3 g; 50 mg/mL

Usual Adult Dose for Testicular Cancer

1.2 g/m2 IV over at least 30 minutes daily for 5 consecutive days; repeat every 3 weeks or after recovery from hematologic toxicity

Comments:

To prevent bladder toxicity, this drug should be given with extensive hydration (at least 2 liters of oral or IV fluid daily).
Mesna should be used to reduce hemorrhagic cystitis.

Use: For use in combination with other antineoplastic agents for third-line chemotherapy of germ cell testicular cancer

Dose adjustment may be required; however, no specific guidelines have been suggested. Caution recommended.

Use with caution.

US BOXED WARNINGS:
MYELOSUPPRESSION:

Recommendation:

NEUROTOXICITY:

Recommendation:

UROTOXICITY:

Recommendation:

Hemorrhagic cystitis can be severe and can be reduced by the prophylactic use of mesna.

CONTRAINDICATIONS:

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

This drug is dialyzable; however, no dose adjustment guidelines have been reported.

Administration advice:

This drug should be administered as a slow IV infusion lasting a minimum of 30 minutes.

Storage requirements:

Reconstitution/preparation techniques:

The manufacturer product information should be consulted. Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit.

IV compatibility:

This drug is compatible with 5% dextrose injection, 0.9% sodium chloride injection, Lactated Ringer's injection, and sterile water for injection.

General:

Handling and preparation of this drug should be in accordance with current guidelines on safe handling of cytotoxic agents.
Skin reactions associated with accidental exposure to this drug may occur. Wear impervious gloves when handling vials and solutions. If this drug contacts the skin or mucosa, immediately wash the skin thoroughly with soap and water or rinse the mucosa with copious amounts of water.

Monitoring: