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Idarubicin Dosage

Medically reviewed by Drugs.com. Last updated on Jun 26, 2024.

Applies to the following strengths: 1 mg/mL; 5 mg; 10 mg; 20 mg

Usual Adult Dose for Acute Myeloid Leukemia

12 mg/m2 daily for 3 days by slow (10 to 15 min) IV administration in combination with cytarabine
Maximum recommended cumulative lifetime dose for the IV formulation: 150 mg/m2

In patients with unequivocal evidence of leukemia after the first induction course, a second course may be administered.

Comment:


Use: For the treatment of acute myeloid leukemia (AML) in combination with other approved antileukemic drug (including French-American-British [FAB] classifications M1 through M7)

Usual Adult Dose for Acute Nonlymphocytic Leukemia

12 mg/m2 daily for 3 days by slow (10 to 15 min) IV administration in combination with cytarabine
Maximum recommended cumulative lifetime dose for the IV formulation: 150 mg/m2

In patients with unequivocal evidence of leukemia after the first induction course, a second course may be administered.

Comment:


Use: For the treatment of acute myeloid leukemia (AML) in combination with other approved antileukemic drug (including French-American-British [FAB] classifications M1 through M7)

Renal Dose Adjustments

Liver Dose Adjustments

Dose Adjustments

Administration of the second course should be delayed in patients who experience severe mucositis, until recovery from this toxicity has occurred, and a dose reduction of 25% is recommended.

Precautions

US BOXED WARNINGS:


Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

General:


Reconstitution/preparation techniques:
Refer to the manufacturer product information.

IV compatibility:
Refer to the manufacturer product information.

Monitoring:

Patient advice:

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.