Guanabenz Dosage
Applies to the following strengths: 4 mg; 8 mg
Usual Adult Dose for:
Additional dosage information:
Usual Adult Dose for Hypertension
Initial dose: 4 mg orally twice a day, whether used alone or in combination with a thiazide diuretic.
Maintenance dose: 4 to 8 mg orally twice a day. The maximum dose studied is 32 mg twice a day, although doses this high are rarely needed.
Renal Dose Adjustments
Data not available
Liver Dose Adjustments
Because guanabenz is extensively metabolized by the liver, it is recommended that dose increments be made cautiously in patients with liver disease.
Dose Adjustments
Titrate dosage upwards in increments of 4 to 8 mg every 1 to 2 weeks. Patients with liver impairment should have dosage adjustments made cautiously.
Precautions
If to be discontinued, gradual withdrawal over 1 to 2 weeks should occur to reduce the risk of rebound hypertension.
Safety and effectiveness have not been established in pediatric patients (less than 18 years of age).
Dialysis
Data not available
Other Comments
The maximum recommended dose is 32 mg orally twice a day (rarely needed).
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