Crenessity Dosage

Generic name: CRINECERFONT 25mg
Dosage form: capsule, oral solution
Drug class: Adrenal corticosteroid inhibitors

Medically reviewed by Drugs.com. Last updated on Dec 10, 2024.

2.1 Important Administration Information

Patients receiving CRENESSITY should continue glucocorticoid replacement therapy for the adrenal insufficiency associated with congenital adrenal hyperplasia (see Warning and Precautions (5.2).

Androstenedione levels can be assessed beginning four weeks after CRENESSITY initiation to inform reduction in glucocorticoid dosage as clinically indicated. Do not reduce the glucocorticoid dosage below that required for replacement therapy.

2.2 Recommended Dosage and Administration

Recommended Dosage for Adults

The recommended CRENESSITY dosage for adults is 100 mg orally, twice daily with a meal in the morning and evening.

Recommended Dosage for Pediatric Patients 4 Years of Age and Older

The recommended CRENESSITY dosage for pediatric patients 4 years of age and older is weight-based and administered orally, twice daily with a meal in the morning and evening (see Table 1).

Table 1: Recommended CRENESSITY Weight-Based Dosage for Pediatric Patients 4 Years of Age and Older

Weight	Dosage Regimen with a Meal
10 kg to less than 20 kg	25 mg orally twice daily
20 kg to less than 55 kg	50 mg orally twice daily
Greater than or equal to 55 kg	100 mg orally twice daily

2.3 Dosage Modifications for Concomitant Use with Strong CYP3A4 Inducers

Adults

In adults, increase the CRENESSITY dosage to 200 mg orally, twice daily with a meal in the morning and evening when used concomitantly with strong CYP3A4 inducers.

Pediatric Patients 4 Years of Age and Older

In pediatric patients, increase the CRENESSITY dosage with a meal in the morning and evening when used concomitantly with strong CYP3A4 inducers as shown in Table 2.

Table 2: Dosage Increase of CRENESSITY for Use with Strong CYP3A4 Inducers in Pediatric Patients 4 Years of Age and Older

Weight	Dosage Regimen with a Meal
10 kg to less than 20 kg	50 mg orally twice daily
20 kg to less than 55 kg	100 mg orally twice daily
Greater than or equal to <55 kg	200 mg orally twice daily

2.4 Dosage Modifications for Concomitant Use with Moderate CYP3A4 Inducers

Adults

In adults, increase the CRENESSITY dosage to 200 mg orally with the evening meal when used concomitantly with moderate CYP3A4 inducers. The CRENESSITY dosage of 100 mg with the morning meal remains unchanged.

Pediatric Patients 4 Years of Age and Older

In pediatric patients, increase the CRENESSITY dosage with the evening meal when used concomitantly with moderate CYP3A4 inducers as shown in Table 3.

Table 3. Dosage Increase of CRENESSITY for Use with Moderate CYP3A4 Inducers in Pediatric Patients 4 Years of Age and Older

	Dosage Regimen with a Meal
Weight	Morning Dose	Evening Dose
10 kg to less than 20 kg	25 mg orally	50 mg orally
20 kg to less than 55 kg	50 mg orally	100 mg orally
Greater than or equal to 55 kg	100 mg orally	200 mg orally

2.5 Administration Instructions

Administer CRENESSITY orally, twice daily, with a meal in the morning and evening.

CRENESSITY Capsules

Take CRENESSITY capsules orally and swallow whole with liquid.

CRENESSITY Oral Solution

Refer patients and/or caregivers to the Instructions for Use (IFU) for complete administration instructions.

Discard any unused CRENESSITY oral solution after 30 days of first opening the bottle.

2.6 Missed Doses

If a dose or doses are missed, advise the patient to take one dose of CRENESSITY as soon as possible (even if it is soon before the next scheduled dose) and then to resume the regular dosing schedule.