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Cimetidine Dosage

Medically reviewed by Drugs.com. Last updated on May 29, 2023.

Applies to the following strengths: 300 mg; 400 mg; 800 mg; 300 mg/5 mL; 900 mg-0.9%/250 mL; 480 mg/100 mL-0.9%; 900 mg-0.9%/500 mL; 1200 mg-0.9%/500 mL; 900 mg-0.9%/1000 mL; 1200 mg-0.9%/1000 mL; 150 mg/mL; 300 mg/50 mL-NaCl 0.9%; 200 mg; 100 mg; 200 mg/20 mL

Usual Adult Dose for Duodenal Ulcer

800 to 1600 mg orally once a day at bedtime


Comments:

Use: Short-term treatment of active duodenal ulcer

Usual Adult Dose for Duodenal Ulcer Prophylaxis

400 mg orally once a day at bedtime


Use: Maintenance therapy for duodenal ulcer patients at reduced dosage after healing of active ulcer

Usual Adult Dose for Gastric Ulcer

800 mg orally once a day at bedtime OR 300 mg orally 4 times a day (with meals and at bedtime)


Comments:

Use: Short-term treatment of active benign gastric ulcer

Usual Adult Dose for Zollinger-Ellison Syndrome

300 mg orally 4 times a day (with meals and at bedtime)


Comments:

Use: Treatment of pathological hypersecretory conditions (e.g., Zollinger-Ellison syndrome, systemic mastocytosis, multiple endocrine adenomas)

Usual Adult Dose for Erosive Esophagitis

800 mg orally 2 times a day OR 400 mg orally 4 times a day


Comments:

Uses:

Usual Adult Dose for Gastroesophageal Reflux Disease

800 mg orally 2 times a day OR 400 mg orally 4 times a day


Comments:

Uses:

Usual Adult Dose for Dyspepsia

OVER-THE-COUNTER (OTC) FORMULATIONS:


Uses:

Usual Pediatric Dose for Duodenal Ulcer

Pediatric Patients:


Uses:

Usual Pediatric Dose for Duodenal Ulcer Prophylaxis

Pediatric Patients:


Uses:

Usual Pediatric Dose for Erosive Esophagitis

Pediatric Patients:


Uses:

Usual Pediatric Dose for Gastric Ulcer

Pediatric Patients:


Uses:

Usual Pediatric Dose for Gastroesophageal Reflux Disease

Pediatric Patients:


Uses:

Usual Pediatric Dose for Stress Ulcer Prophylaxis

Pediatric Patients:


Uses:

Usual Pediatric Dose for Zollinger-Ellison Syndrome

Pediatric Patients:


Uses:

Usual Pediatric Dose for Dyspepsia

12 years and older:
OTC FORMULATIONS:


Uses:

Renal Dose Adjustments

Severe renal dysfunction: 300 mg orally every 12 hours

Comment: The frequency may be increased to every 8 hours (or even further) with caution if the patient's condition requires.

Severe renal failure: The lowest frequency of dosing compatible with adequate patient response should be used.

Liver Dose Adjustments

Liver dysfunction with renal dysfunction: Dose adjustment(s) may be required; however, no specific guidelines have been suggested. Caution recommended.

Dose Adjustments

Therapeutic drug monitoring/range: Intragastric secretory rate or 10 mEq/hour or less

Patients with endoscopically demonstrated ulcers larger than 1 cm AND are heavy smokers (e.g., smoke 1 or more pack of cigarettes/day): Consider 1600 mg orally once a day at bedtime for 4 weeks OR 800 mg orally once a day for 8 weeks.

Precautions

CONTRAINDICATIONS:


Safety and efficacy of OTC formulations have not been established in patients younger than 12 years.
Safety and efficacy of prescription formulations have not been established in patients younger than 16 years.

Consult WARNINGS section for additional precautions.

Dialysis

Hemodialysis: The dose should be given at the end of the hemodialysis session.
Peritoneal dialysis: Data not available

Other Comments

Administration advice:


Storage requirements:

General:

Monitoring:

Patient advice:

Frequently asked questions

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.