CaverJect Dosage

Erectile Dysfunction of Vasculogenic, Psychogenic, or Mixed Etiology

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Initiate dosing with 2.5 mcg of CAVERJECT intracavernosally, as recommended.

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If there is a partial response at 2.5 mcg, administer another dose of 2.5 mcg within 1 hour. Use a new vial for each dose of CAVERJECT.

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During titration, no more than 2 doses should be given within a 24-hour period.

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If additional titration is required, administer doses in increments of 5 to 10 mcg at least 24 hours apart.

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The optimal dose should produce an erection suitable for intercourse that does not exceed a duration of 1 hour.

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The patient must stay in the health care provider’s office until complete detumescence occurs.

Repeat the titration as necessary until the optimal dose is achieved. Doses greater than 60 mcg are not recommended.

Erectile Dysfunction of Pure Neurogenic Etiology (e.g., Spinal Cord Injury).

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Initiate dosing with 1.25 mcg of CAVERJECT intracavernosally, as recommended.

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If there is a partial response at 1.25 mcg, administer another dose of 1.25 mcg within 1 hour. Use a new vial for each dose of CAVERJECT.

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If additional titration is required, administer a dose of 5 mcg at least 24 hours later.

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During titration, no more than 2 doses should be given within a 24-hour period.

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The optimal dose should produce an erection suitable for intercourse that does not exceed a duration of 1 hour.

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The patient must stay in the health care provider’s office until complete detumescence occurs.

Repeat the titration as necessary until the optimal dose is achieved. Doses greater than 60 mcg are not recommended.

Maintenance Dosage for Patient Home Use

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Once the dose of CAVERJECT has been determined in the health care provider’s office, additional dose adjustment may be required after consultation with the health care provider. Adjust the dose in accordance with the titration guidelines described above.

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The recommended frequency of injection is no more than 3 times weekly, with at least 24 hours between each dose.

Adjunct to the Diagnosis of Erectile Dysfunction

As an adjunct to the diagnosis of erectile dysfunction, inject CAVERJECT intracavernosally and monitor patients for the occurrence of an erection. Extensions of this testing are the use of CAVERJECT as an adjunct to laboratory investigations, such as duplex or Doppler ultrasound imaging. For any of these tests, use a single dose of CAVERJECT that induces a rigid erection. Use the dose regimen for ‘Erectile Dysfunction of Vasculogenic, Psychogenic, or Mixed Etiology’ above.

Supplies Needed and Not Supplied With CAVERJECT

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1 mL of the diluent (bacteriostatic water for injection)

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1 mL to 3 mL syringe, dependent on the titrated dose

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21 to 27 gauge needle for reconstitution

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29 or 30 gauge one-half inch needle for injection

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alcohol swabs

Reconstitution Instructions

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CAVERJECT vial(s): Using the correct strength vial containing 20 mcg or 40 mcg of CAVERJECT, use a 1 mL to 3 mL syringe, a 21 to 27 gauge needle, and 1 mL of the diluent (bacteriostatic water for injection) for reconstitution. Reconstitution results in CAVERJECT 20 mcg/mL or 40 mcg/mL.

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Visually inspect the solution in the vial for particulate matter and discoloration. Do not use the solution if it is cloudy, colored or contains particles.

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Draw the dose of CAVERJECT into the syringe.

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Replace the needle used for reconstitution with a 29 or 30 gauge one-half inch needle prior to injection.

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The reconstituted solution should be used within 24 hours when stored at or below 25°C (77°F).

Refer to the Patient Information and Instructions for Use in the FDA-approved patient labeling for the complete detailed instructions on reconstitution and needle preparation steps.