Cabometyx Dosage

Generic name: cabozantinib s-malate 60mg
Dosage form: tablet
Drug classes: Multikinase inhibitors, VEGF/VEGFR inhibitors

Medically reviewed by Drugs.com. Last updated on Mar 26, 2025.

Important Dosage Information and Recommended Evaluation and Testing Before Initiating CABOMETYX

Do not substitute CABOMETYX tablets with cabozantinib capsules.
Administer CABOMETYX on an empty stomach. Administer at least 1 hour before or at least 2 hours after eating [see Clinical Pharmacology (12.3)].
Stop treatment with CABOMETYX 3 weeks prior to scheduled surgery, including dental surgery to reduce the risk of hemorrhage. Do not administer CABOMETYX for at least 2 weeks after major surgery and until adequate wound healing.

Recommended Dosage for Renal Cell Carcinoma

The recommended dosage of CABOMETYX as a single agent is 60 mg orally once daily until disease progression or unacceptable toxicity.

The recommended dosage of CABOMETYX in combination with nivolumab is provided in the following table:

Table 1. Recommended Dosage of CABOMETYX in Combination with Nivolumab
Recommended Dosage	Duration of Therapy
CABOMETYX 40 mg orally once daily	Until disease progression or unacceptable toxicity
Nivolumab 240 mg every 2 weeks (30-minute intravenous infusion) or 480 mg every 4 weeks (30- minute intravenous infusion)	Until disease progression or unacceptable toxicity for up to 2 years

Recommended Dosage for Hepatocellular Carcinoma

The recommended dosage of CABOMETYX as a single agent is 60 mg orally once daily until disease progression or unacceptable toxicity.

Recommended Dosage for Differentiated Thyroid Cancer and Neuroendocrine Tumors

Table 2 provides the recommended dosage of CABOMETYX for differentiated thyroid cancer (DTC) and neuroendocrine tumors (NET).

Table 2: Recommended Dosages for DTC and NET
Adult and pediatric patients 12 years of age and older with bodyweight greater than or equal to 40 kg	60 mg orally once daily until disease progression or unacceptable toxicity
Pediatric patients 12 years of age and older with bodyweight less than 40 kg	40 mg orally once daily until disease progression or unacceptable toxicity

Dosage Modifications for Adverse Reactions

Withhold CABOMETYX for:

Intolerable Grade 2 adverse reactions
Grade 3 or 4 adverse reactions
Osteonecrosis of the jaw

Upon resolution/improvement (i.e., return to baseline or resolution to Grade 1) of an adverse reaction, reduce the dose as follows:

Table 3. Recommended Dosage Reductions for CABOMETYX for Adverse Reactions
Recommended Dosage	First Dosage Reduction To	Second Dosage Reduction To
* If previously receiving lowest dose, resume at same dose. If lowest dose not tolerated, discontinue CABOMETYX.
CABOMETYX 60 mg daily in adult and pediatric patients 12 years of age and older with bodyweight greater than or equal to 40 kg	40 mg daily	20 mg daily*
CABOMETYX 40 mg daily in pediatric patients 12 years of age and older with bodyweight less than 40 kg	20 mg daily	20 mg every other day*
CABOMETYX 40 mg daily in combination with nivolumab	20 mg daily	20 mg every other day*

Table 4. Recommended Dosage Modifications for CABOMETYX Adverse Reactions
Adverse Reaction	Severity*	CABOMETYX Dosage Modification
* Graded according to National Cancer Institute Common Terminology Criteria for Adverse Events (NCI CTCAE version 5.0)
Hemorrhage	Grade 3 or 4	Permanently discontinue CABOMETYX
Perforations and Fistulas	Any grade gastrointestinal perforation or Grade 4 fistula	Permanently discontinue CABOMETYX
Thrombotic Events	Any grade acute myocardial infarction or Grade 2 or higher cerebral infarction or Grade 3 or 4 arterial thromboembolic events or Grade 4 venous thromboembolic events	Permanently discontinue CABOMETYX
Hypertension and Hypertensive Crisis	Grade 3	Withhold CABOMETYX until hypertension is adequately controlled to ≤Grade 2 Resume at reduced dose Permanently discontinue CABOMETYX for hypertension that cannot be controlled
Hypertension and Hypertensive Crisis	Grade 4	Permanently discontinue CABOMETYX
Diarrhea	Grade 2, Grade 3, or Grade 4	Withhold CABOMETYX until ≤Grade 1 Resume at reduced dose
Palmar-Plantar Erythrodysesthesia	Intolerable Grade 2 or Grade 3	Withhold CABOMETYX until ≤Grade 1 Resume at reduced dose
Proteinuria	Grade 2 or 3	Withhold CABOMETYX until improvement to ≤ Grade 1 proteinuria Resume at a reduced dose Permanently discontinue CABOMETYX for nephrotic syndrome
Osteonecrosis of the jaw (ONJ)	Any grade	Withhold CABOMETYX for development of ONJ until complete resolution Resume at reduced dose
Reversible Posterior Leukoencephalopathy Syndrome	Any grade	Permanently discontinue CABOMETYX
Other Adverse Reactions	Intolerable Grade 2, or Grade 3, or Grade 4	Withhold CABOMETYX until improvement to baseline or ≤Grade 1 Resume at reduced dose

The following table represents dosage modifications for the drug administered in combination that are different from those described above for CABOMETYX or in the Full Prescribing Information:

Table 5. Recommended Specific Dosage Modifications for Hepatic Adverse Reactions for Combination
* Consider corticosteroid therapy for hepatic adverse reactions if CABOMETYX is withheld or discontinued when administered in combination with nivolumab † After recovery, rechallenge with one or both of CABOMETYX and nivolumab may be considered. If rechallenging with nivolumab with or without CABOMETYX, refer to nivolumab Prescribing Information.
CABOMETYX in combination with nivolumab	ALT or AST >3 times ULN but ≤10 times ULN with concurrent total bilirubin <2 times ULN	Withhold* both CABOMETYX and nivolumab until adverse reactions recover† to Grades 0 or 1
	ALT or AST >10 times ULN or >3 times ULN with concurrent total bilirubin ≥2 times ULN	Permanently discontinue both CABOMETYX and nivolumab

When administering CABOMETYX in combination with nivolumab for the treatment of advanced RCC, refer to the nivolumab prescribing information.

Dosage Modifications for Coadministration with Strong CYP3A4 Inhibitors

Reduce the daily CABOMETYX dose by 20 mg (for example, from 60 mg to 40 mg daily or from 40 mg to 20 mg daily or from 20 mg daily to 20 mg every other day in pediatric patients 12 years of age and older with bodyweight less than 40 kg). Resume the dose that was used prior to initiating the strong CYP3A4 inhibitor 2 to 3 days after discontinuation of the strong inhibitor.

Dosage Modifications for Coadministration with Strong or Moderate CYP3A4 Inducers

Increase the daily CABOMETYX dose by 20 mg (for example, from 60 mg to 80 mg daily or from 40 mg to 60 mg daily) as tolerated. Resume the dose that was used prior to initiating the strong or moderate CYP3A4 inducer 2 to 3 days after discontinuation of the inducer. Do not exceed a daily dose of 80 mg.

Dosage Modifications for Patients with Hepatic Impairment

Reduce the starting dose of CABOMETYX 60 mg daily to 40 mg daily or 40 mg daily to 20 mg daily (for pediatric patients 12 years of age and older with bodyweight less than 40 kg) in patients with moderate hepatic impairment (Child-Pugh B).

Administration

Administer CABOMETYX on an empty stomach. Administer at least 1 hour before or at least 2 hours after eating.

Swallow CABOMETYX tablets whole. Do not crush, chew, or split CABOMETYX tablets.
Do not take a missed dose within 12 hours of the next dose.
Modify the CABOMETYX dose for patients taking drugs known to moderately or strongly induce CYP3A4 or strongly inhibit CYP3A4 and for patients with moderate hepatic impairment.