Bretylium Dosage

Usual Adult Dose for Ventricular Fibrillation

Initial dose: 5 mg/kg undiluted IV once.
If V Fib persists: 10 mg/kg undiluted IV and repeat as necessary.
Maintenance: 1 to 2 mg/min by continuous IV infusion or
5 to 10 mg/kg diluted IV over 8 minutes every 6 hours.

Usual Adult Dose for Ventricular Tachycardia

Initial dose: 5 to 10 mg/kg diluted IV over > 8 minutes.
If arrhythmia persists: Give subsequent doses at 1 to 2 hour intervals
Maintenance: 1 to 2 mg/min by continuous IV infusion or
5 to 10 mg/kg diluted IV over 8 minutes every 6 hours.
IM: 5 to 10 mg/kg undiluted.
If the arrhythmia persists: Give subsequent doses at 1 to 2 hour intervals.
Maintenance dose: The same dose every 6 to 8 hours.

Usual Pediatric Dose for Ventricular Fibrillation

> 1 year: Initial dose: 5 mg/kg/dose IV.
If V Fib persists: 10 mg/kg at 15 to 30 minute intervals to a maximum dose of 30 mg/kg.
Maintenance dose: 5 to 10 mg/kg IV every 6 hours.

Usual Pediatric Dose for Ventricular Tachycardia

> 1 year: 5 to 10 mg/kg IV every 6 hours.

Renal Dose Adjustments

CrCl < 10 mL/min: A reduction in dose to 25% is suggested.

CrCl 10-50 mL/min: A reduction in dose to 25% to 50% is suggested.

Liver Dose Adjustments

Data not available

Dialysis

Bretylium is not dialyzable (0%-5%) via hemo- or peritoneal dialysis. Supplemental doses are not needed.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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