Skip to main content

Bendamustine Dosage

Medically reviewed by Drugs.com. Last updated on Jun 17, 2024.

Applies to the following strengths: 25 mg/mL; 25 mg; 100 mg; 90 mg/mL

Usual Adult Dose for Chronic Lymphocytic Leukemia

100 mg/m2 IV on Days 1 and 2 of a 28-day cycle
Duration of Therapy: Up to 6 cycles

Comments:


Use: For the treatment of patients with chronic lymphocytic leukemia

Usual Adult Dose for non-Hodgkin's Lymphoma

120 mg/m2 IV on Days 1 and 2 of a 21-day cycle
Duration of Therapy: Up to 8 cycles

Comments:


Use: For the treatment of patients with indolent B-cell non-Hodgkin lymphoma that has progressed during or within six months of treatment with rituximab or a rituximab-containing regimen

Renal Dose Adjustments

Liver Dose Adjustments

Dose Adjustments

Chronic Lymphocytic Leukemia (CLL) or Non-Hodgkin Lymphoma (NHL):
Grade 4 Hematologic Toxicity or Clinically Significant Grade 2 or Greater Non-Hematologic Toxicity: Delay treatment; reinitiate therapy at a physician's discretion once non-hematologic toxicity has recovered to Grade 1 or less and/or absolute neutrophil count (ANC) 1 x 10(9)/L or greater and platelets 75 x 10(9)/L or greater; dose reduction may be warranted.

CLL:
Grade 3 or Greater Hematologic Toxicity: Reduce dose to 50 mg/m2 on Days 1 and 2 of each cycle.


Clinically Significant Grade 3 or Greater Non-Hematologic Toxicity: Reduce dose to 50 mg/m2 on Days 1 and 2 of each cycle.

NHL:
Grade 4 Hematologic Toxicity or Grade 3 or Greater Non-Hematologic Toxicity: Reduce dose to 90 mg/m2 on Days 1 and 2 of each cycle.

Precautions

CONTRAINDICATIONS:
Patients with a known hypersensitivity (e.g., anaphylactic and anaphylactoid reactions) to the active component

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Dialysis

This drug is dialyzable to a small extent; however, no dose adjustment guidelines have been reported.

Other Comments

Administration Advice:


Storage Requirements:

Reconstitution/Preparation Techniques:

IV Compatibility:

General:

Monitoring:

Patient Advice:

Frequently asked questions

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.