Aspirin / Caffeine Dosage

Medically reviewed by Drugs.com. Last updated on Mar 22, 2024.

Usual Adult Dose for Fever

Aspirin 325 to 650 mg orally every 4 hours or Aspirin 500 to 1000 mg orally every 6 hours with Caffeine (in doses up to 65 mg) as needed
Maximum number of daily doses: 4
Maximum daily dose: Aspirin: 4000 mg

Comments:

• Dosing ranges are provided; consult product labeling for specific dosing.
• Caffeine use should be limited when using this product.

Uses: For the temporary relief of minor aches and pains due to headache, toothache, muscular aches, backache, arthritis, and menstrual cramps; for the temporary relief of pain and fever due to colds.

Usual Adult Dose for Pain

Aspirin 325 to 650 mg orally every 4 hours or Aspirin 500 to 1000 mg orally every 6 hours with Caffeine (in doses up to 65 mg) as needed
Maximum number of daily doses: 4
Maximum daily dose: Aspirin: 4000 mg

Comments:

• Dosing ranges are provided; consult product labeling for specific dosing.
• Caffeine use should be limited when using this product.

Uses: For the temporary relief of minor aches and pains due to headache, toothache, muscular aches, backache, arthritis, and menstrual cramps; for the temporary relief of pain and fever due to colds.

Usual Pediatric Dose for Fever

12 years or older:

Aspirin 325 to 650 mg orally every 4 hours or Aspirin 500 to 1000 mg orally every 6 hours with Caffeine (in doses up to 65 mg) as needed
Maximum number of daily doses: 4
Maximum daily dose: Aspirin: 4000 mg

Comments:

• Dosing ranges are provided; consult product labeling for specific dosing.
• Caffeine use should be limited when using this product.

Uses: For the temporary relief of minor aches and pains due to headache, toothache, muscular aches, backache, arthritis, and menstrual cramps; for the temporary relief of pain and fever due to colds.

Usual Pediatric Dose for Pain

12 years or older:

Aspirin 325 to 650 mg orally every 4 hours or Aspirin 500 to 1000 mg orally every 6 hours with Caffeine (in doses up to 65 mg) as needed
Maximum number of daily doses: 4
Maximum daily dose: Aspirin: 4000 mg

Comments:

• Dosing ranges are provided; consult product labeling for specific dosing.
• Caffeine use should be limited when using this product.

Uses: For the temporary relief of minor aches and pains due to headache, toothache, muscular aches, backache, arthritis, and menstrual cramps; for the temporary relief of pain and fever due to colds.

Renal Dose Adjustments

Use with caution; routine aspirin use is not recommended in patients with severe renal impairment (CrCl less than 10 mL/minute) due to an increased risk of salicylate toxicity

Liver Dose Adjustments

Use with caution; routine aspirin use is not recommended in patients with severe hepatic impairment due to the potential for increased risk of clinically significant bleeding and other adverse effects.

Dose Adjustments

Elderly: Use with caution due to increased risk of adverse events; consider the maximal dose in elderly patients to be less than that the adult maximal dose

Precautions

CONTRAINDICATIONS:

• Hypersensitivity to active substances, aspirin, other salicylates, nonsteroidal anti-inflammatory agents (NSAIDs) or any or any product excipients

Safety and efficacy have not been established in patients younger than 12 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:
Tablets: Take orally with a full glass of water

Effervescent Tablets: Fully dissolve tablets in 16 ounces of water and drink

Powder:

• To open, fold on line to expose notch, then tear at notch or use scissors
• Place 1 or 2 powders on tongue and swallow with or without water
• Drink a full glass of water or liquid with each dose

General:

• Effervescent tablets may contain phenylalanine; see labeling
• Adolescents recovering from chicken pox or flu-like symptoms should not use this product due to risk of Reye's syndrome.

Monitoring:

• Monitor for signs and symptoms of bleeding

Patient advice:

• Patients should be instructed to read the product labeling.
• Patients should understand that this product is for occasional use; they should be advised to contact their healthcare provider if their symptoms worsen while using this product or last more than 10 days.
• Patients should be advised to avoid caffeine-containing drugs, foods, or drinks because too much caffeine may cause nervousness, irritability, sleeplessness, or palpitations.
• Patients should be instructed to seek immediate medical assistance if they have an allergic reaction.
• Patients should contact their healthcare professional promptly if they experience signs of stomach bleeding such as vomiting blood, black or bloody stools, or stomach pain that does not get better.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer