Amoxicillin / Clarithromycin / Omeprazole Dosage

Medically reviewed by Drugs.com. Last updated on Sep 4, 2024.

Applies to the following strengths: 500 mg-500 mg-20 mg

Usual Adult Dose for:

Duodenal Ulcer
Helicobacter pylori Infection

Additional dosage information:

Renal Dose Adjustments
Liver Dose Adjustments
Dose Adjustments
Precautions
Dialysis
Other Comments

Usual Adult Dose for Duodenal Ulcer

Amoxicillin 500 mg-clarithromycin 500 mg-omeprazole 20 mg orally 2 times a day

Duration of therapy: 10 days

Comments:

Doses should be given in the morning and evening before eating a meal.
An additional 18 days of treatment with omeprazole 20 mg orally once a day is recommended for patients with an ulcer at initiation of treatment.

Use: Eradication of Helicobacter pylori in patients with active duodenal ulcer of a history of duodenal ulcer disease

Usual Adult Dose for Helicobacter pylori Infection

Amoxicillin 500 mg-clarithromycin 500 mg-omeprazole 20 mg orally 2 times a day

Duration of therapy: 10 days

Comments:

Doses should be given in the morning and evening before eating a meal.
An additional 18 days of treatment with omeprazole 20 mg orally once a day is recommended for patients with an ulcer at initiation of treatment.

Use: Eradication of Helicobacter pylori in patients with active duodenal ulcer of a history of duodenal ulcer disease

Renal Dose Adjustments

Mild to moderate renal dysfunction No adjustment recommended.
Severe renal dysfunction: Consider longer dosage intervals.

Liver Dose Adjustments

Hepatic dysfunction: Not recommended.

Dose Adjustments

Asian patients: Use is not recommended unless clearly needed.

Patients with severe renal dysfunction and hepatic dysfunction: Prolonged dose intervals should be considered.

Precautions

Safety and efficacy have not been established in children.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:

This drug should be swallowed whole; chewing or crushing should be avoided.
The regimen should be given before meals.

Storage requirements:

Protect from light and moisture.

General:

Eradication of H pylori reduces the risk of duodenal ulcer recurrence.
This drug may be used in patients with active or a one-year history of duodenal ulcer.

Monitoring:

Hepatic: Hepatic function tests
Hematologic: Hematopoietic function tests
Renal: Renal function tests

Patient advice:

Tell patients that it is important to complete the full regimen.
Instruct patients to seek medical attention if signs/symptoms of hypersensitivity, Clostridium difficile-associated diarrhea, hypomagnesemia, or systemic cutaneous lupus erythematosus occur.