Amitiza Dosage

Generic name: LUBIPROSTONE 8ug
Dosage form: capsule, gelatin coated
Drug class: Chloride channel activators

Medically reviewed by Drugs.com. Last updated on Mar 12, 2025.

Recommended Dosage

The recommended oral dosage of Amitiza by indication and adjustments for patients with moderate (Child Pugh Class B) and severe (Child Pugh Class C) hepatic impairment are shown in Table 1.

Table 1. Recommended Dosage Regimen
	CIC and OIC	IBS-C
* If the dose is tolerated and an adequate response has not been obtained after an appropriate interval, doses can then be escalated to full dosing with appropriate monitoring of patient response.
Recommended Adult Dosage Regimen	24 mcg twice daily	8 mcg twice daily
Dosage Adjustment for Hepatic Impairment	Moderate Impairment (Child-Pugh Class B): 16 mcg twice daily*	Moderate Impairment (Child-Pugh Class B): No adjustment necessary
Dosage Adjustment for Hepatic Impairment	Severe Impairment (Child-Pugh Class C): 8 mcg twice daily*	Severe Impairment (Child-Pugh Class C): 8 mcg once daily*

Administration Instructions

Take Amitiza orally with food and water.
Swallow capsules whole and do not break apart or chew.
Physicians and patients should periodically assess the need for continued therapy.