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Tivdak Disease Interactions

There are 3 disease interactions with Tivdak (tisotumab vedotin).

Moderate

Tisotumab vedotin (applies to Tivdak) hepatic impairment

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Liver Disease

Avoid the use of tisotumab vedotin in patients with moderate or severe hepatic impairment.

References

  1. (2021) "Product Information. Tivdak (tisotumab vedotin)." Seagen Inc
Moderate

Tisotumab vedotin (applies to Tivdak) ocular toxicity

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Visual Defect/Disturbance

Ocular adverse events are very common in patients receiving treatment with tisotumab vedotin. Patients with baseline visual disturbances should be monitored and if any symptoms worsen should be evaluated promptly by an eye care provider. Reduce dosage, withhold or permanently discontinue treatment based on the severity of the symptoms.

References

  1. (2021) "Product Information. Tivdak (tisotumab vedotin)." Seagen Inc
Moderate

Tisotumab vedotin (applies to Tivdak) peripheral neuropathy

Moderate Potential Hazard, Moderate plausibility.

Patients receiving treatment with tisotumab vedotin may have peripheral neuropathy adverse reactions. Patients with preexisting peripheral neuropathy should be monitored. Reduce dosage, withhold, or permanently discontinue treatment based on the severity of symptoms.

References

  1. (2021) "Product Information. Tivdak (tisotumab vedotin)." Seagen Inc

Tivdak drug interactions

There are 305 drug interactions with Tivdak (tisotumab vedotin).

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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