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Xenazine Disease Interactions

There are 7 disease interactions with Xenazine (tetrabenazine).

Major

Tetrabenazine (applies to Xenazine) cardiac arrhythmias

Major Potential Hazard, Moderate plausibility.

Tetrabenazine can cause an increase in the corrected QT interval. QT prolongation can lead to the development of ventricular arrhythmias. The use of tetrabenazine should be avoided in patients with congenital long QT syndrome and in patients with a history of arrhythmias.

References

  1. (2008) "Product Information. Xenazine (tetrabenazine)." Prestwick Pharmaceuticals Inc
Major

Tetrabenazine (applies to Xenazine) depression

Major Potential Hazard, Moderate plausibility.

The use of tetrabenazine is contraindicated in patients with untreated or uncontrolled depression. Tetrabenazine can increase the risk of depression and suicidal thoughts and behavior.

References

  1. (2008) "Product Information. Xenazine (tetrabenazine)." Prestwick Pharmaceuticals Inc
Major

Tetrabenazine (applies to Xenazine) hepatic impairment

Major Potential Hazard, Moderate plausibility. Applicable conditions: Liver Disease

The use of tetrabenazine is contraindicated in patients with hepatic impairment. The safety and efficacy of exposure to the drug and other metabolites are unknown and it is not possible to adjust the dosage in hepatic impairment to ensure safe use.

References

  1. (2008) "Product Information. Xenazine (tetrabenazine)." Prestwick Pharmaceuticals Inc
Major

Tetrabenazine (applies to Xenazine) Huntington's disease

Major Potential Hazard, Moderate plausibility. Applicable conditions: Huntington Disease

Patients with Huntington disease are prone to depression. Tetrabenazine can increase the risk of depression and suicidal thoughts and should be used with caution in patients with Huntington's disease. The benefits and risks of treatment should be considered before starting therapy, and patients should be under close observation for emergence or worsening of depression symptoms. The family and caregivers should also be informed of this risk and should be instructed to report any changes in behavior or any concerns to the treating physician.

References

  1. (2008) "Product Information. Xenazine (tetrabenazine)." Prestwick Pharmaceuticals Inc
Moderate

Tetrabenazine (applies to Xenazine) dysphagia

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Huntington Disease

Tetrabenazine reduces dopaminergic transmission and can be associated with esophageal dysmotility and dysphagia. Caution should be exercised when used in patients with conditions that predispose to dysphagia. Special caution is advised in patients with Huntington's disease as dysphagia is a common symptom and it could lead to aspiration pneumonia.

References

  1. (2008) "Product Information. Xenazine (tetrabenazine)." Prestwick Pharmaceuticals Inc
Moderate

Tetrabenazine (applies to Xenazine) hyperprolactinemia

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Osteoporosis, Breast Cancer

Tetrabenazine can elevate serum prolactin concentrations. This should be considered when therapy will be prescribed in patients with previously detected breast cancer. Additionally, chronic increase in serum prolactin has been associated with low levels of estrogen and increase risk of osteoporosis. If there is suspicion of hyperprolactinemia, appropriate laboratory testing is advised and treatment discontinuation should be considered.

References

  1. (2008) "Product Information. Xenazine (tetrabenazine)." Prestwick Pharmaceuticals Inc
Moderate

Tetrabenazine (applies to Xenazine) hypotension

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Syncope

Tetrabenazine can induce postural dizziness and syncope and should be used with caution in patients who are vulnerable to hypotension.

References

  1. (2008) "Product Information. Xenazine (tetrabenazine)." Prestwick Pharmaceuticals Inc

Xenazine drug interactions

There are 535 drug interactions with Xenazine (tetrabenazine).

Xenazine alcohol/food interactions

There is 1 alcohol/food interaction with Xenazine (tetrabenazine).

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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