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Qinlock Disease Interactions

There are 3 disease interactions with Qinlock (ripretinib).

Moderate

Ripretinib (applies to Qinlock) cardiac dysfunction

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Heart Disease, Cardiovascular Disease

Ripretinib may cause cardiac dysfunction. The safety of ripretinib has not been assessed in patients with a baseline ejection fraction below 50%. Assess ejection fraction by echocardiogram or multiple gated acquisition (MUGA) scan prior to initiating treatment with ripretinib and during treatment, as clinically indicated. Permanently discontinue therapy for Grade 3 or 4 left ventricular systolic dysfunction.

References

  1. (2023) "Product Information. Qinlock (ripretinib)." Deciphera Pharmaceuticals
Moderate

Ripretinib (applies to Qinlock) hypertension

Moderate Potential Hazard, Moderate plausibility.

Ripretinib may cause hypertension. It is recommended to control blood pressure prior to initiating therapy and monitor blood pressure as clinically indicated during treatment. Based on severity, withhold treatment with ripretinib and resume at the same or reduced dose or permanently discontinue. Do not initiate ripretinib in patients with uncontrolled hypertension.

References

  1. (2023) "Product Information. Qinlock (ripretinib)." Deciphera Pharmaceuticals
Moderate

Ripretinib (applies to Qinlock) wound

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Bleeding, Coagulation Defect

Ripretinib has the potential to affect wound healing adversely. Do not administer ripretinib for at least two weeks following major surgery and until adequate wound healing. It is recommended to withhold ripretinib for at least one week before elective surgery. Care should be exercised when using this agent in patients with impaired wound complications. The safety of this agent after the resolution of wound healing complications has not been established.

References

  1. (2023) "Product Information. Qinlock (ripretinib)." Deciphera Pharmaceuticals

Qinlock drug interactions

There are 324 drug interactions with Qinlock (ripretinib).

Qinlock alcohol/food interactions

There are 2 alcohol/food interactions with Qinlock (ripretinib).

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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