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HyperRAB S/D Disease Interactions

There are 2 disease interactions with HyperRAB S/D (rabies immune globulin, human).

Major

Rabies (applies to HyperRAB S/D) antibody response

Major Potential Hazard, High plausibility. Applicable conditions: Immunodeficiency

Patients with primary or acquired deficient/impaired immune response (immunosuppressive therapy, genetic, splenic dysfunction, immunodeficiency disorders) may have reduced antibody response to immunizations. Deferral of immunosuppressive therapy may be considered pending completion of post-exposure therapy unless essential for treatment of other conditions.

References

  1. (2001) "Product Information. Bayrab (rabies immune globulin, human)." Bayer
Major

Vaccines (applies to HyperRAB S/D) IM injection

Major Potential Hazard, Moderate plausibility. Applicable conditions: Thrombocytopenia, Thrombocytopathy, Coagulation Defect

In patients with thrombocytopenia or coagulation disorders, intramuscular injections may produce bleeding and hematomas. Patients with a platelet count less than 50,000/mm3 are at an increased risk. Caution is advised if the vaccine (e.g., plague vaccine, hepatitis A and B vaccines, and aluminum-adsorbed DTaP, DTP, DT, or Td) must be administered intramuscularly. The risk of bleeding may be minimized by vaccination immediately after the administration of replacement factor, use of a 23-gauge (or smaller) needle, and immediate application of direct pressure to the vaccination site for at least 2 minutes.

References

  1. (2001) "Product Information. Plague Vaccine (plague vaccine)." Greer Laboratories Inc
  2. American Academy of Pediatrics. Committee on Infectious Diseases; Peter G, ed. (1997) "Red BooK: Report of the Committee on Infectious Diseases." Grove Village, IL: American Academy of Pediatrics
  3. "Product Information. Cholera Vaccine (cholera vaccine)." Wyeth-Ayerst Laboratories
  4. "Product Information. Havrix (HepA) (hepatitis A adult vaccine)." SmithKline Beecham
  5. (2022) "Product Information. Engerix-B (HepB) (hepatitis B adult vaccine)." Apothecon Inc
  6. (2005) "Product Information. Menactra (meningococcal conjugate vaccine)." sanofi pasteur
  7. (2022) "Product Information. ActHIB (Hib) (haemophilus b conjugate (PRP-T) vaccine)." sanofi pasteur
  8. (2010) "Product Information. Imogam Rabies-HT (rabies immune globulin, human)." sanofi pasteur
  9. (2015) "Product Information. Hyperrab S/D (rabies immune globulin, human)." Grifols Therapeutics
  10. (2022) "Product Information. Bexsero (meningococcal group B vaccine)." Novartis Vaccines & Diagnostics Inc
View all 10 references

HyperRAB S/D drug interactions

There are 24 drug interactions with HyperRAB S/D (rabies immune globulin, human).

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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