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Naloxone Disease Interactions

There are 4 disease interactions with naloxone.

Major

Naloxone (applies to naloxone) CV disorders

Major Potential Hazard, Moderate plausibility. Applicable conditions: Cardiovascular Disease

Therapy with naloxone in patients with preexisting cardiovascular disorders should be closely monitored for hypotension, hypertension, ventricular tachycardia or fibrillation, and pulmonary edema in an appropriate healthcare setting. Clinical monitoring of cardiovascular status is recommended.

Moderate

Naloxone (applies to naloxone) liver disease

Moderate Potential Hazard, Moderate plausibility.

The safety and effectiveness of naloxone injection in patients with liver disease have not been established. Caution should be exercised when naloxone is administered to patients with liver disease.

Moderate

Naloxone (applies to naloxone) renal

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Renal Dysfunction

The safety and effectiveness of naloxone injection in patients with renal insufficiency/failure have not been established. Caution should be exercised when naloxone is administered to these patients.

Moderate

Naloxone (applies to naloxone) septic shock

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Sepsis

Naloxone has been shown in some cases of septic shock to produce a rise in blood pressure that may last up to several hours; however, this pressor response has not been demonstrated to improve patient survival. In some studies, treatment with naloxone in the setting of septic shock has been associated with adverse effects, including agitation, nausea and vomiting, pulmonary edema, hypotension, cardiac arrhythmias, and seizures. The decision to use naloxone in septic shock should be exercised with caution, particularly in patients who may have underlying pain or have previously received opioid therapy and may have developed opioid tolerance.

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Naloxone drug interactions

There are 30 drug interactions with naloxone.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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