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Miconazole Disease Interactions

There are 2 disease interactions with miconazole.

Moderate

Miconazole (applies to miconazole) liver disease

Moderate Potential Hazard, Moderate plausibility.

The use of miconazole in patients with liver disease has not been adequately studied, although it is known that miconazole is primarily metabolized by the liver. Therapy with miconazole should be administered cautiously in patients with liver disease, and the dosing adjusted or discontinued according to clinical response.

References (3)
  1. Daneshmend TK, Warnock DW (1983) "Clinical pharmacokinetics of systemic antifungal drugs." Clin Pharmacokinet, 8, p. 17-42
  2. Lewi PJ, Boelaert J, Daneels R, et al. (1976) "Pharmacokinetic profile of intravenous miconazole in man." Eur J Clin Pharmacol, 10, p. 49-54
  3. "Product Information. Monistat 7 (miconazole topical)." Ortho McNeil Pharmaceutical

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Minor

Miconazole (applies to miconazole) hyperlipidemia

Minor Potential Hazard, Moderate plausibility.

Elevations in cholesterol and triglyceride levels may occur in patients receiving intravenous miconazole and are attributed to the drug vehicle, Cremophor EL (polyethoxylated castor oil). These increases are reversible upon discontinuation of miconazole therapy. Clinicians should be cognizant of these effects when interpreting lab results of hyperlipidemic patients during treatment with miconazole.

References (6)
  1. Naito HK, McHenry MC, Lewis LA (1980) "Drug-induced dyslipoproteinemia: a report of two cases." Clin Chem, 26, p. 163-8
  2. Heel RC, Brogden RN, Pakes GE, Speight TM, Avery GS (1980) "Miconazole: a preliminary review of its therapeutic efficacy in systemic fungal infections." Drugs, 19, p. 7-30
  3. Rose HD, Roth DA, Barboriak JJ (1979) "Hyperlipidemia related to miconazole therapy." Ann Intern Med, 91, p. 491-2
  4. Wade TR, Jones HE, Chanda JJ (1979) "Intravenous miconazole therapy of mycotic infections." Arch Intern Med, 139, p. 784-6
  5. Bagnarello AG, Lewis LA, McHenry MC, Weinstein AJ, Naito HK, McCullough AJ, Lederman RJ, Gavan TL (1977) "Unusual serum lipoprotein abnormality induced by the vehicle of miconazole." N Engl J Med, 296, p. 497-9
  6. "Product Information. Monistat 7 (miconazole topical)." Ortho McNeil Pharmaceutical

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Miconazole drug interactions

There are 297 drug interactions with miconazole.

Miconazole alcohol/food interactions

There is 1 alcohol/food interaction with miconazole.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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