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Methotrimeprazine Disease Interactions

There is 1 disease interaction with methotrimeprazine.

Major

Atypical antipsychotic agents (applies to methotrimeprazine) dementia

Major Potential Hazard, High plausibility.

Older patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death; although the causes were varied, most of the deaths appeared to be either cardiovascular (e.g., heart failure, sudden death) or infectious (e.g., pneumonia) in nature. A causal relationship with antipsychotic use has not been established. In controlled trials in older patients with dementia-related psychosis, patients randomized to risperidone, aripiprazole, and olanzapine had higher incidence of cerebrovascular adverse events (e.g., stroke, transient ischemic attack), including fatalities, compared to patients treated with placebo. These agents are not approved for the treatment of patients with dementia-related psychosis.

References

  1. (2001) "Product Information. Clozaril (clozapine)." Novartis Pharmaceuticals
  2. (2001) "Product Information. Risperdal (risperidone)." Janssen Pharmaceuticals
  3. (2001) "Product Information. Zyprexa (olanzapine)." Lilly, Eli and Company
  4. (2001) "Product Information. Seroquel (quetiapine)." Astra-Zeneca Pharmaceuticals
  5. (2001) "Product Information. Geodon (ziprasidone)." Pfizer U.S. Pharmaceuticals
  6. (2002) "Product Information. Abilify (aripiprazole)." Bristol-Myers Squibb
  7. (2007) "Product Information. Invega (paliperidone)." Janssen Pharmaceuticals
  8. (2009) "Product Information. Fanapt (iloperidone)." Vanda Pharmaceuticals Inc
  9. (2009) "Product Information. Saphris (asenapine)." Schering-Plough Corporation
  10. (2010) "Product Information. Latuda (lurasidone)." Sunovion Pharmaceuticals Inc
  11. (2015) "Product Information. Rexulti (brexpiprazole)." Otsuka American Pharmaceuticals Inc
  12. (2015) "Product Information. Vraylar (cariprazine)." Actavis Pharma, Inc.
  13. (2016) "Product Information. Nuplazid (pimavanserin)." Accelis Pharma
  14. (2022) "Product Information. Caplyta (lumateperone)." Intra-Cellular Therapies, Inc., SUPPL-9
View all 14 references

Methotrimeprazine drug interactions

There are 648 drug interactions with methotrimeprazine.

Methotrimeprazine alcohol/food interactions

There is 1 alcohol/food interaction with methotrimeprazine.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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