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Recorlev Disease Interactions

There are 3 disease interactions with Recorlev (levoketoconazole).

Major

Levoketoconazole (applies to Recorlev) liver impairment/hepatotoxicity

Major Potential Hazard, Moderate plausibility. Applicable conditions: Liver Disease

Levoketoconazole has been associated with serious hepatotoxicity and it is contraindicated in patients with cirrhosis, acute liver disease or poorly controlled chronic liver disease, baseline AST or ALT > 3 times the upper limit of normal, recurrent symptomatic cholelithiasis, a prior history of drug induced liver injury due to ketoconazole or any azole antifungal therapy that required discontinuation of treatment, or extensive metastatic liver disease.

References

  1. (2022) "Product Information. Recorlev (levoketoconazole)." Xeris Pharmaceuticals Inc
Major

Levoketoconazole (applies to Recorlev) QT prolongation

Major Potential Hazard, Moderate plausibility. Applicable conditions: Arrhythmias

Levoketoconazole is associated with dose-related QT interval prolongation which may result in life-threatening ventricular dysrhythmias such as torsades de pointes. This drug is contraindicated in patients with prolonged QTcF interval > 470 msec at baseline, history of torsades de pointes, ventricular tachycardia, ventricular fibrillation, or prolonged QT syndrome. Patients receiving treatment should be monitored with an ECG prior to and during treatment.

References

  1. (2022) "Product Information. Recorlev (levoketoconazole)." Xeris Pharmaceuticals Inc
Moderate

Levoketoconazole (applies to Recorlev) hypokalemia/hypomagnesemia

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Magnesium Imbalance

Electrolyte imbalances such as hypokalemia and hypomagnesemia must be treated and corrected before starting treatment with levoketoconazole.

References

  1. (2022) "Product Information. Recorlev (levoketoconazole)." Xeris Pharmaceuticals Inc

Recorlev drug interactions

There are 820 drug interactions with Recorlev (levoketoconazole).

Recorlev alcohol/food interactions

There is 1 alcohol/food interaction with Recorlev (levoketoconazole).

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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