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Letermovir Disease Interactions

There are 2 disease interactions with letermovir.

Moderate

Letermovir (applies to letermovir) hepatic dysfunction

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Liver Disease

The use of letermovir is not recommended for patients with severe liver dysfunction (Child-Pugh C). No dosage adjustment of letermovir is required for patients with mild or moderate liver dysfunction (Child-Pugh A or B).

References

  1. (2023) "Product Information. Prevymis (letermovir)." Merck Sharp & Dohme LLC, SUPPL-11
Moderate

Letermovir (applies to letermovir) renal impairment

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Renal Dysfunction

Hydroxypropyl betadex present in the IV letermovir formulation is mainly eliminated by glomerular filtration. Decreased elimination of hydroxypropyl betadex has been reported in patients with severe renal dysfunction. Serum creatinine levels should be closely monitored in patients with CrCl less than 50 mL/min using letermovir injection because accumulation of the IV vehicle (hydroxypropyl betadex) could occur. In patients with CrCl greater than 10 mL/min, no dosage adjustment of letermovir is required based on renal dysfunction. The safety of letermovir in patients with end-stage renal disease (CrCl less than 10 mL/min), including patients on dialysis, is unknown.

References

  1. (2023) "Product Information. Prevymis (letermovir)." Merck Sharp & Dohme LLC, SUPPL-11

Letermovir drug interactions

There are 397 drug interactions with letermovir.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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