Laronidase Disease Interactions
There is 1 disease interaction with laronidase.
Laronidase (applies to laronidase) cardiac/pulmonary impairment
Major Potential Hazard, Moderate plausibility. Applicable conditions: Heart Disease, Fever, Fluid Retention
Patients with compromised respiratory function or acute respiratory disease may be at risk of serious acute exacerbation of their respiratory compromise due to infusion reactions during laronidase therapy and require additional monitoring. Patients with compromised respiratory function or acute febrile or respiratory illness at the time of laronidase infusion may be at higher risk of life-threatening complications from hypersensitivity reactions. Careful consideration should be given to the patient's clinical status before laronidase administration and delaying the laronidase infusion should be considered.
Caution is recommended when administering laronidase to patients susceptible to fluid overload, or patients with acute underlying respiratory illness or compromised cardiac and/or respiratory function for whom fluid restriction is indicated; these patients may be at risk of serious exacerbation of their cardiac or respiratory status during infusions. Appropriate medical support and monitoring measures should be readily available during laronidase infusion, and some patients may require prolonged observation times that should be based on the needs of each patient.
Laronidase drug interactions
There are 2 drug interactions with laronidase.
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- Drug class: lysosomal enzymes
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Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.