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Lugol's Disease Interactions

There are 4 disease interactions with Lugol's (iodine / potassium iodide).

Moderate

Iodide salts (applies to Lugol's) hyperthyroidism

Moderate Potential Hazard, Low plausibility.

The use of iodide salts has been associated with the exacerbation or precipitation of hyperthyroidism in patients previously euthyroid. Induction of goiter has been reported in patients with hyperthyroidism. Iodide salts should be administered cautiously in patients with hyperthyroidism.

References (8)
  1. Iancu T, Boyanower Y, Laurian N (1974) "Congenital goiter due to maternal ingestion of iodide." Am J Dis Child, 128, p. 528-30
  2. Ayromlooi J (1972) "Congenital goiter due to maternal ingestion of iodides." Obstet Gynecol, 39, p. 818-22
  3. Denham MJ, Himsworth RL (1974) "Hyperthyroidism induced by potassium iodide given in the course of 125I-fibrinogen test." Age Ageing, 3, p. 221-5
  4. Yalow RS (1983) "Risks in mass distribution of potassium iodide." Bull N Y Acad Med, 59, p. 1020-7
  5. "Product Information. SSKI (saturated) (potassium iodide)." Upsher-Smith Laboratories Inc
  6. (2022) "Product Information. Pima (potassium iodide)." Fleming and Company
  7. Carswell F, Kerr MM, Hutchison JH (1970) "Congenital goitre and hypothyroidism produced by maternal ingestion of iodides." Lancet, 1, p. 1241-3
  8. Parmelle A, et al. (1940) "Three cases of newborn infants with congential goiter due to ingestion of iodide." Am J Obstet Gynecol, 40, p. 145-7
Moderate

Potassium iodide (applies to Lugol's) heart disease

Moderate Potential Hazard, Moderate plausibility.

Potassium iodide should not be used in patients that have nodular thyroid disease and heart disease. Patients experiencing irregular heartbeats or chest pain should be instructed to stop treatment with potassium iodide.

References (2)
  1. "Product Information. SSKI (saturated) (potassium iodide)." Upsher-Smith Laboratories Inc
  2. (2022) "Product Information. Pima (potassium iodide)." Fleming and Company
Moderate

Potassium iodide (applies to Lugol's) dermatitis herpetiformis

Moderate Potential Hazard, Moderate plausibility.

Potassium iodide should not be used in patients that have or have ever had dermatitis herpetiformis.

References (2)
  1. "Product Information. SSKI (saturated) (potassium iodide)." Upsher-Smith Laboratories Inc
  2. (2022) "Product Information. Pima (potassium iodide)." Fleming and Company
Moderate

Potassium iodide (applies to Lugol's) vasculitis

Moderate Potential Hazard, Moderate plausibility.

People who are allergic to iodide or have hypocomplementemic vasculitis should not take potassium iodide.

References (2)
  1. "Product Information. SSKI (saturated) (potassium iodide)." Upsher-Smith Laboratories Inc
  2. (2022) "Product Information. Pima (potassium iodide)." Fleming and Company

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Lugol's drug interactions

There are 50 drug interactions with Lugol's (iodine / potassium iodide).

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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