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Twinrix Disease Interactions

There are 4 disease interactions with Twinrix (hepatitis a adult vaccine / hepatitis b adult vaccine).

Moderate

Hepatitis A adult vaccine (applies to Twinrix) liver disease

Moderate Potential Hazard, Moderate plausibility.

The use of hepatitis A adult vaccine in patients with chronic liver disease may have lower antibody response to the vaccine. Monitoring is recommended when vaccinating these patients.

References

  1. "Product Information. Havrix (HepA) (hepatitis A adult vaccine)." SmithKline Beecham
Moderate

Hepatitis A vaccine (applies to Twinrix) immunocompromised

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Immunodeficiency

The use of hepatitis A vaccine in immunocompromised persons, including individuals receiving immunosuppressive therapy, may result in diminished immune response to the vaccine and these patients may not be protected against hepatitis A virus. Monitoring is recommended when vaccinating these patients.

References

  1. "Product Information. Havrix (HepA) (hepatitis A adult vaccine)." SmithKline Beecham
  2. (2022) "Product Information. Vaqta (hepatitis A adult vaccine)." Merck & Co., Inc
Moderate

Hepatitis A vaccine (applies to Twinrix) liver dysfunction

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Liver Disease

The use of hepatitis A vaccine in patients with chronic liver disease may result in lower antibody response. Care should be exercised when using this agent in patients with liver disease.

References

  1. "Product Information. Havrix (HepA) (hepatitis A adult vaccine)." SmithKline Beecham
Moderate

Hepatitis B vaccine (applies to Twinrix) hemophilia

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Bleeding Associated with Coagulation Defect

Hepatitis B vaccine (adult and pediatric) is usually for intramuscular administration. However, it may be administered subcutaneously to persons at risk for hemorrhage following intramuscular injections (e.g., hemophiliacs), although it may result in lower antibody response. Additionally, when other aluminum- absorbed vaccines have been administered subcutaneously, an increased incidence of local reactions including subcutaneous nodules has been observed. Therefore, consider subcutaneous administration only in persons who are at risk of hemorrhage following intramuscular injections.

References

  1. (2022) "Product Information. Engerix-B Pediatric (HepB) (hepatitis B pediatric vaccine)." GlaxoSmithKline
  2. (2022) "Product Information. Recombivax HB Pediatric/Adolescent (hepatitis B pediatric vaccine)." Merck & Co., Inc

Twinrix drug interactions

There are 288 drug interactions with Twinrix (hepatitis a adult vaccine / hepatitis b adult vaccine).

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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