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Tavalisse Disease Interactions

There are 4 disease interactions with Tavalisse (fostamatinib).

Moderate

Fostamatinib (applies to Tavalisse) diarrhea

Moderate Potential Hazard, Moderate plausibility.

The use of fostamatinib may cause diarrhea. Monitor patients for the development of diarrhea during treatment with fostamatinib. It is recommended to manage diarrhea using supportive care measures, including dietary changes, hydration and/or antidiarrheal medication, early after the onset of symptoms. Interrupt, dose reduce, or discontinue treatment if diarrhea becomes severe (Grade 3 or above). Care should be exercised when using this agent in patients with diarrhea.

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Moderate

Fostamatinib (applies to Tavalisse) hepatotoxicity

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Liver Disease

The use of fostamatinib may result in elevated liver function tests, mainly ALT and AST. It is recommended to monitor liver function tests monthly during treatment. Treatment with fostamatinib should be interrupted, reduced, or discontinued if ALT or AST increase more than 3 × ULN. Use care using this agent in patients with liver problems.

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Moderate

Fostamatinib (applies to Tavalisse) hypertension

Moderate Potential Hazard, Moderate plausibility.

The use of fostamatinib may cause hypertension. It is recommended to monitor blood pressure every 2 weeks until stable, then monthly and to adjust or initiate antihypertensive therapy to ensure maintenance of blood pressure control during treatment. If increased blood pressure persists despite appropriate therapy, therapy interruption, reduction or discontinuation may be necessary. Caution should be exercised when using this agent in patients with pre-existing hypertension as they may be more susceptible to the hypertensive effects of fostamatinib.

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Moderate

Fostamatinib (applies to Tavalisse) neutropenia

Moderate Potential Hazard, Moderate plausibility.

Neutropenia has been reported in patients treated with fostamatinib. It is recommended to monitor the ANC monthly, and for infection during treatment and manage toxicity with treatment interruption, reduction or discontinuation.

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Tavalisse drug interactions

There are 468 drug interactions with Tavalisse (fostamatinib).

Tavalisse alcohol/food interactions

There is 1 alcohol/food interaction with Tavalisse (fostamatinib).

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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