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Fomepizole Disease Interactions

There is 1 disease interaction with fomepizole.

Moderate

Fomepizole (applies to fomepizole) hepatic/renal dysfunction

Moderate Potential Hazard, Low plausibility. Applicable conditions: Liver Disease

The pharmacokinetic disposition of fomepizole has not been determined in patients with hepatic and/or renal impairment. Fomepizole is extensively metabolized by the liver. Following multiple dosing, fomepizole induces its own metabolism and the rate of elimination is increased. About 1% to 3.5% of fomepizole is eliminated unchanged in the urine. Therapy with fomepizole should be administered cautiously in patients with compromised hepatic and/or renal function. Fomepizole is dialyzable and the frequency of dosing should be increased to every 4 hours during hemodialysis.

References

  1. (2001) "Product Information. Antizol (fomepizole)." Jazz Pharmaceuticals

Fomepizole drug interactions

There is 1 drug interaction with fomepizole.

Fomepizole alcohol/food interactions

There is 1 alcohol/food interaction with fomepizole.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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