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Flumazenil Disease Interactions

There are 4 disease interactions with flumazenil.

Major

Flumazenil (applies to flumazenil) seizures

Major Potential Hazard, Moderate plausibility. Applicable conditions: Head Injury

Flumazenil has been associated with seizure activity, particularly in patients receiving repeated doses of benzodiazepines for long term sedation, acute overdose involving concurrent cyclic antidepressants, or head injury where it may alter cerebral blood flow in patients receiving benzodiazepines. Therapy with flumazenil should be administered cautiously in patients with a history of or predisposition to seizures.

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Moderate

Flumazenil (applies to flumazenil) alcoholism

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Drug Abuse/Dependence

Flumazenil should be used with caution in patients with alcoholism and other drug dependencies due to the increased frequency of benzodiazepine tolerance and dependence observed in these patient populations.

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Moderate

Flumazenil (applies to flumazenil) hepatic dysfunction

Moderate Potential Hazard, High plausibility. Applicable conditions: Liver Disease, Congestive Heart Failure

Flumazenil is a highly extracted drug, dependent on blood flow, and primarily metabolized by the liver. Hepatic clearance is decreased 40% to 60 % in patients with moderate hepatic dysfunction and 75% in patients with severe hepatic dysfunction. Care should be exercised as the metabolic and therapeutic activity of flumazenil may be altered in patients with compromised hepatic function or conditions that decrease systemic blood flow. Following the initial dose, subsequent doses or the frequency of administration should be reduced.

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Moderate

Flumazenil (applies to flumazenil) psychoses

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Psychosis

Panic attacks have been induced by flumazenil in patients with a history of panic attacks. Emotional lability, including crying, depersonalization, euphoria, depression, dysphoria and paranoia have also been reported. Therapy with flumazenil should be administered cautiously in patients with or predisposed to psychosis, particularly panic attacks.

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Flumazenil drug interactions

There are 29 drug interactions with flumazenil.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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