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Delavirdine Disease Interactions

There are 2 disease interactions with delavirdine.

Moderate

Delavirdine (applies to delavirdine) achlorhydria

Moderate Potential Hazard, High plausibility.

Patients with achlorhydria should take delavirdine with an acidic beverage such as orange or cranberry juice, presumably to improve absorption. Although the effects of acidic beverages on delavirdine absorption have not been studied, delavirdine is known to be poorly soluble when pH is greater than 3.

References

  1. (2001) "Product Information. Rescriptor (delavirdine)." Pharmacia and Upjohn
Moderate

Delavirdine (applies to delavirdine) liver disease

Moderate Potential Hazard, High plausibility.

Delavirdine is primarily metabolized by the liver. Patients with liver disease may be at greater risk for toxicities and adverse effects from delavirdine due to decreased drug clearance. Therapy with delavirdine should be administered cautiously in patients with liver disease.

References

  1. (2001) "Product Information. Rescriptor (delavirdine)." Pharmacia and Upjohn

Delavirdine drug interactions

There are 484 drug interactions with delavirdine.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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