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Dalfampridine Disease Interactions

There are 2 disease interactions with dalfampridine.

Major

Dalfampridine (applies to dalfampridine) renal impairment

Major Potential Hazard, Moderate plausibility. Applicable conditions: Renal Dysfunction

Dalfampridine is contraindicated in patients with moderate or severe renal impairment (CrCl<=50 mL/min). Dalfampridine is eliminated through the kidneys primarily as unchanged drug and its clearance is decreased in patients with renal impairment and is significantly correlated with creatinine clearance.

References

  1. (2010) "Product Information. Ampyra (dalfampridine)." Acorda Therapeutics
Major

Dalfampridine (applies to dalfampridine) seizures

Major Potential Hazard, Moderate plausibility.

Dalfampridine is contraindicated in patients with a history of seizures. Dalfampridine can cause seizures and it is recommended to permanently discontinue treatment in patients who have a seizure while on treatment.

References

  1. (2010) "Product Information. Ampyra (dalfampridine)." Acorda Therapeutics

Dalfampridine drug interactions

There are 48 drug interactions with dalfampridine.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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