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Clofazimine Disease Interactions

There are 3 disease interactions with clofazimine.

Moderate

Clofazimine (applies to clofazimine) GI effects

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Diarrhea, Inflammatory Bowel Disease

The use of clofazimine has been associated with severe abdominal symptoms including splenic infarction, bowel obstruction, and GI bleeding. Death has been reported following severe abdominal symptoms. Crystalline deposits have been found in the intestinal mucosa, liver, gallbladder, bile, spleen, adrenals, subcutaneous fat, mesenteric lymph nodes, muscles, bone and skin. Clofazimine should be administered cautiously in patients with GI problems such as abdominal pain and diarrhea.

Moderate

Clofazimine (applies to clofazimine) hepatic dysfunction

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Liver Disease

Use of clofazimine should be avoided in patients with hepatic dysfunction (Child-Pugh A, B, or C).

References

  1. (2019) "Product Information. Lamprene (clofazimine)." Novartis Pharmaceuticals
Moderate

Clofazimine (applies to clofazimine) renal dysfunction

Moderate Potential Hazard, High plausibility.

Clofazimine should be used with caution in patients with severe renal dysfunction. No dose adjustments are recommended in patients with mild to moderate renal dysfunction.

References

  1. (2019) "Product Information. Lamprene (clofazimine)." Novartis Pharmaceuticals

Clofazimine drug interactions

There are 298 drug interactions with clofazimine.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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