Calcium chloride Disease Interactions
There are 5 disease interactions with calcium chloride.
Calcium chloride (applies to calcium chloride) acidosis
Major Potential Hazard, High plausibility. Applicable conditions: Renal Dysfunction, Pulmonary Impairment
Calcium chloride is acidifying. Therapy with calcium chloride should be administered cautiously in patients with or predisposed to acidosis, including those with renal disease, cor pulmonale, severe respiratory obstruction, or respiratory failure. Calcium chloride should not be administered as therapy for hypocalcemia in patients with acidosis associated with renal failure. Clinical monitoring of acid/base balance and calcium concentrations is necessary during calcium chloride therapy.
References
- "Product Information. Calcium chloride 10% (calcium chloride)." Astra USA, Westborough, MA.
Calcium salts (applies to calcium chloride) calcium- phosphate calcifications
Major Potential Hazard, High plausibility. Applicable conditions: Phosphate Imbalance
Elevated serum concentrations of calcium and phosphate can exceed the solubility level and result in calcium- phosphate precipitates that deposit in vascular and renal systems as well as other soft tissues of the body. Therapy with calcium should be administered with extreme caution in patients with hyperphosphatemia (hypoparathyroidism or severe renal impairment). Administration of oral calcium acetate or calcium carbonate, in addition to providing calcium, complexes phosphates within the GI tract. These complexes are eliminated in the feces. Clinical monitoring of serum calcium and phosphate concentrations is necessary.
References
- "Product Information. Posture (calcium phosphate, tribasic)." Whitehall-Robbins
- (2001) "Product Information. Neo-Calglucon (calcium glubionate)." Sandoz Pharmaceuticals Corporation
Calcium salts (applies to calcium chloride) cardiac contraction/conduction
Major Potential Hazard, High plausibility. Applicable conditions: Arrhythmias
Calcium is involved in cardiac muscle contraction and electrical impulse conduction. Therapy with calcium salt formulations (particularly IV) should be administered cautiously to patients with cardiac disease. Patients receiving cardiac glycosides and concomitant IV calcium may experience arrhythmias. Therapy with IV calcium should be administered slowly and at reduced dosages in patients with cardiac disease.
References
- "Product Information. Posture (calcium phosphate, tribasic)." Whitehall-Robbins
- (2001) "Product Information. Neo-Calglucon (calcium glubionate)." Sandoz Pharmaceuticals Corporation
Calcium salts (applies to calcium chloride) renal dysfunction
Major Potential Hazard, High plausibility.
Absorption of oral calcium formulations may be altered and elimination of calcium by the kidney decreased with renal impairment. Hyperphosphatemia occurs during renal failure. Calcium acetate or calcium carbonate, in addition to providing calcium, complexes phosphates within the GI tract. Calcium carbonate can partially correct metabolic acidosis associated with chronic renal failure. Clinical monitoring of renal function and serum calcium and phosphate concentrations is necessary.
References
- "Product Information. Posture (calcium phosphate, tribasic)." Whitehall-Robbins
- (2001) "Product Information. Neo-Calglucon (calcium glubionate)." Sandoz Pharmaceuticals Corporation
Calcium salts (applies to calcium chloride) sarcoidosis
Major Potential Hazard, High plausibility.
Hypercalciuria, with or without hypercalcemia, may occasionally occur in patients with sarcoidosis. Elevated calcium levels may result from increased intestinal absorption of calcium, which is related to the extrarenal production of vitamin D by mononuclear phagocytes present within the sarcoid granuloma. Therapy with calcium salts should be administered cautiously and only if necessary in patients with sarcoidosis.
References
- "Product Information. Posture (calcium phosphate, tribasic)." Whitehall-Robbins
- (2001) "Product Information. Neo-Calglucon (calcium glubionate)." Sandoz Pharmaceuticals Corporation
- Braunwald E, Hauser SL, Kasper DL, Fauci AS, Isselbacher KJ, Longo DL, Martin JB, eds., Wilson JD (1998) "Harrison's Principles of Internal Medicine." New York, NY: McGraw-Hill Health Professionals Division
Calcium chloride drug interactions
There are 37 drug interactions with calcium chloride.
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Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
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