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Benzocaine/phenol/povidone iodine topical Disease Interactions

There are 2 disease interactions with benzocaine / phenol / povidone iodine topical.

Moderate

Benzocaine (applies to benzocaine/phenol/povidone iodine topical) methemoglobinemia

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: G-6-PD Deficiency

Rarely, benzocaine has induced methemoglobinemia resulting in respiratory distress and cyanosis. Therapy with benzocaine should be administered cautiously to patients with or predisposed to methemoglobinemia. If life-threatening or severe methemoglobinemia develops, methylene blue infused at a dosage of 1 to 2 mg/kg body weight will rapidly reverse or improve the condition except in G-6-PD-deficient patients.

References

  1. (2001) "Product Information. Americaine (benzocaine topical)." Novartis Consumer Health
  2. (2001) "Product Information. Americaine Otic (benzocaine otic)." Medeva Pharmaceuticals
Moderate

Iodine (applies to benzocaine/phenol/povidone iodine topical) thyroid/metabolic abnormality

Moderate Potential Hazard, Low plausibility. Applicable conditions: Hypothyroidism, Hyperthyroidism

Elevated serum iodine levels can lead to altered thyroid function and metabolic abnormalities in patients receiving oral iodine therapy as well as topical therapy. Iodine should be used cautiously in patients with thyroid disorders. Monitoring thyroid function is recommended.

References

  1. "Product Information. Betadine (povidone iodine topical)." Akorn Inc
  2. "Product Information. Betadine (povidone iodine topical)." Purdue Frederick Company
  3. (2001) "Product Information. Iodopen (sodium iodide)." Fujisawa

Benzocaine/phenol/povidone iodine topical drug interactions

There are 46 drug interactions with benzocaine / phenol / povidone iodine topical.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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