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Avatrombopag Disease Interactions

There are 2 disease interactions with avatrombopag.

Moderate

Avatrombopag (applies to avatrombopag) severe renal dysfunction

Moderate Potential Hazard, Moderate plausibility.

The effect of severe renal impairment (CrCl < 30 mL/min) including patients requiring hemodialysis on avatrombopag pharmacokinetics is unknown. Caution and monitoring is advised.

References

  1. (2018) "Product Information. Doptelet (avatrombopag)." Dova Pharmaceuticals
Moderate

TPO receptor agonists (applies to avatrombopag) thrombotic / thromboembolic complications

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: History - Thrombotic/Thromboembolic Disorder, Protein C Deficiency, Thrombotic/Thromboembolic Disorder

Thromboembolic complications may result from increases in platelet counts with TPO receptor agonists such as avatrombopag, lusutrombopag, and eltrombopag. Consider the potential for increased risk of thromboembolism when administering these medications to patients with known risk factors for thromboembolism, including genetic prothrombotic conditions (Factor V Leiden, Prothrombin 20210 A, Antithrombin deficiency or Protein C or S deficiency).

References

  1. (2008) "Product Information. Promacta (eltrombopag)." GlaxoSmithKline
  2. (2018) "Product Information. Doptelet (avatrombopag)." Dova Pharmaceuticals
  3. (2018) "Product Information. Mulpleta (lusutrombopag)." Shionogi USA Inc

Avatrombopag drug interactions

There are 83 drug interactions with avatrombopag.

Avatrombopag alcohol/food interactions

There is 1 alcohol/food interaction with avatrombopag.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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