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Icar-C Disease Interactions

There are 5 disease interactions with Icar-C (ascorbic acid/carbonyl iron).

Major

Ferrous salts (applies to Icar-C) hemoglobin abnormalities

Major Potential Hazard, Moderate plausibility. Applicable conditions: Hemoglobinopathy, Blood Transfusion

There is no excretory mechanism for iron. Iron will correct only hemoglobin abnormalities due to iron deficiency and should not be used to treat conditions such as thalassemia, hemosiderosis, hemochromatosis, normocytic anemia (unless iron deficiency exists), or in patients receiving blood transfusions. Clinical monitoring of erythropoietic function and ferritin levels is recommended.

Moderate

Ascorbic acid (vitamin C) (applies to Icar-C) hemolysis

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: G-6-PD Deficiency

Acute hemolysis following administration of high doses of ascorbic acid in patients with glucose-6-phosphate deficiency (G6PD) has been reported. Ascorbic acid should be administered cautiously and dosages modified in patients with G6PD.

Moderate

Ascorbic acid (vitamin C) (applies to Icar-C) kidney stones

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Nephrolithiasis

Large doses of ascorbic acid have lead to hyperoxaluria in 5% of patients. Ascorbic acid can acidify urine resulting in precipitation of urate, cystine, or oxalate stones. Ascorbic acid should be administered cautiously and dosages modified in patients predisposed to renal stones. Clinical monitoring of urinalysis for pH and crystal formation is recommended.

Moderate

Ascorbic acid (vitamin C) (applies to Icar-C) sodium

Moderate Potential Hazard, Low plausibility. Applicable conditions: Hypernatremia, Hypertension

Ascorbic acid preparations contain sodium. The sodium content should be considered when used in patients with sodium restricted diets and conditions require sodium restriction, such as congestive heart failure, hypertension, and fluid retention.

Minor

Ascorbic acid (vitamin C) (applies to Icar-C) dialysis

Minor Potential Hazard, High plausibility. Applicable conditions: hemodialysis

Ascorbic acid is removed by dialysis.

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Icar-C drug interactions

There are 114 drug interactions with Icar-C (ascorbic acid/carbonyl iron).

Icar-C alcohol/food interactions

There are 2 alcohol/food interactions with Icar-C (ascorbic acid/carbonyl iron).

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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