Entereg Disease Interactions
There is 1 disease interaction with Entereg (alvimopan).
Peripheral opioid receptor antagonists (applies to Entereg) intestinal obstruction
Major Potential Hazard, Moderate plausibility. Applicable conditions: Gastrointestinal Obstruction, Diverticulitis, Peptic Ulcer, Inflammatory Bowel Disease
Peripheral opioid receptor antagonists are contraindicated in patients with known or suspected gastrointestinal obstruction, and in patients at increased risk of recurrent obstruction, due to the potential for gastrointestinal perforation. Cases of gastrointestinal perforation have been reported in patients with opioid-induced constipation and advanced illness with conditions that may be associated with localized or diffuse reduction of structure integrity in the wall of the GI tract such as peptic ulcer, diverticular disease, Crohn's disease, infiltrative GI tract malignancies or peritoneal metastases. It is recommended to monitor for the development of severe, persistent, or worsening abdominal pain and to discontinue treatment in patients who develop symptoms. The overall risk- benefit profile should be carefully evaluated before using these agents in patients with these conditions.
Entereg drug interactions
There are 39 drug interactions with Entereg (alvimopan).
Entereg alcohol/food interactions
There is 1 alcohol/food interaction with Entereg (alvimopan).
More about Entereg (alvimopan)
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- During pregnancy
- FDA approval history
- Drug class: peripheral opioid receptor antagonists
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Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
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