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Peripheral opioid receptor antagonists

What are Peripheral opioid receptor antagonists?

Peripheral opioid receptor antagonists bind to the peripheral opioid receptors, such as those in the gastrointestinal tract and block unwanted effects caused by opioids.

They are not able to penetrate the blood brain barrier so do not antagonize central nervous system opioid receptors, therefore the analgesic effects of opioids is not affected.

Peripheral opioid receptor antagonists are given with opioids to prevent opioid-induced constipation.

List of Peripheral opioid receptor antagonists

View by  Generic | Brand
Drug Name Avg. Rating Reviews
naloxegol systemic (Pro)
Brand name: Movantik
4.9
 271 reviews
methylnaltrexone systemic (Pro)
Brand name: Relistor
6.6
 63 reviews
naldemedine systemic (Pro)
Brand name: Symproic
6.3
 33 reviews
alvimopan systemic (Pro)
Brand name: Entereg 		No reviews
For ratings, users were asked how effective they found the medicine while considering positive/adverse effects and ease of use (1 = not effective, 10 = most effective).

See also

Medical conditions treated or associated with peripheral opioid receptor antagonists:

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer