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Pegcetacoplan (Intraocular)

Generic name: pegcetacoplan [ peg-set-a-KOE-plan ]
Brand name: Syfovre
Drug class: Miscellaneous ophthalmic agents

Medically reviewed by Drugs.com. Last updated on Mar 18, 2024.

Uses for pegcetacoplan

Pegcetacoplan injection is used to treat geographic atrophy (GA) secondary to age-related macular degeneration (AMD). AMD is a disorder of the retina in the eye that causes blurred vision or blindness. Pegcetacoplan works by changing the amount of blood that gets to the eye.

This medicine is to be given only by your doctor.

Before using pegcetacoplan

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of pegcetacoplan injection in the pediatric population. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of pegcetacoplan injection in the elderly.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

Proper use of pegcetacoplan

An ophthalmologist (eye doctor) will give you this medicine as a shot into the eye. This medicine is usually given once every 25 to 60 days.

Detailed Pegcetacoplan ophthalmic dosage information

Eylea, Vabysmo, aflibercept ophthalmic, Lucentis, Izervay, Syfovre, pegcetacoplan ophthalmic

Precautions while using pegcetacoplan

Your eye doctor will want to check your progress closely and at regular visits, especially during the first few days after you receive this medicine, to make sure this medicine is working properly and to check for unwanted effects.

Receiving this medicine while you are pregnant can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant during treatment and for at least 40 days after the last dose. If you think you have become pregnant while receiving this medicine, tell your doctor right away.

Serious eye or vision problems (eg, retinal detachment, endophthalmitis, eye infection, increased pressure inside the eye, or neovascular AMD) may occur with this medicine. Check with your eye doctor right away if your have blurred or other change in vision, eye pain, eye redness, seeing flashes or sparks of light, seeing floating spots before the eyes, or a veil or curtain appearing across part of vision, sensitivity of the eye to light, or tearing of the eyes several days after you receive this medicine.

This medicine may cause temporary blurred vision. Do not drive or do anything else that could be dangerous until you can see clearly.

Side Effects of pegcetacoplan

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common

Less common

Rare

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Pegcetacoplan ophthalmic side effects (more detail)

Commonly used brand name(s)

In the U.S.

Available Dosage Forms:

Therapeutic Class: Ophthalmologic Agent

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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