Zoladex Alternatives Compared

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Zoladex (goserelin)	Norethindrone	Lupron Depot (leuprolide)	Enter another drug to compare

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Zoladex (goserelin)	Norethindrone	Lupron Depot (leuprolide)	Enter another drug to compare
Prescription only Prescribed for Prostate Cancer, Breast Cancer - Palliative, Endometriosis, Bleeding Disorder. Zoladex may also be used for purposes not listed in this medication guide.	Prescription only Prescribed for Abnormal Uterine Bleeding, Endometriosis, Amenorrhea, Gender Affirming Hormone Therapy, Birth Control. Norethindrone may also be used for purposes not listed in this medication guide.	Prescription only Lupron Depot is a hormone deprivation treatment that may be used for the palliative care of advanced prostate cancer. The main side effects are hot flashes and general pain and it may cause... View more	Related suggestions Endometriosis Orilissa Progesterone Medroxyprogesterone Provera Danazol Desogestrel / ethinyl estradiol Popular comparisons Zoladex vs Lupron Depot
More about Zoladex (goserelin)	More about Norethindrone	More about Lupron Depot (leuprolide)
Ratings & Reviews
Zoladex has an average rating of 6.6 out of 10 from a total of 103 ratings on Drugs.com. 52% of reviewers reported a positive effect, while 21% reported a negative effect.	Norethindrone has an average rating of 4.9 out of 10 from a total of 1570 ratings on Drugs.com. 33% of reviewers reported a positive effect, while 45% reported a negative effect.	Lupron Depot has an average rating of 5.8 out of 10 from a total of 231 ratings on Drugs.com. 44% of reviewers reported a positive effect, while 32% reported a negative effect.
View all 103 reviews	View all 1570 reviews	View all 231 reviews
Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified.
Hot flashes (50.5%) Weight gain (21.4%) Pain (19.4%) Headaches (17.5%) Mood swings (17.5%) Insomnia (15.5%) Depression (13.6%) View all Zoladex side effects	Bleeding (21.6%) Weight gain (18.0%) Cramps (18.0%) Acne (17.8%) Mood swings (14.5%) Spotting (11.2%) Sore breasts (11.0%) View all Norethindrone side effects	Hot flashes (52.4%) Pain (16.5%) Mood swings (15.6%) Weight gain (13.4%) Headaches (12.1%) Depression (10.8%) Fatigue (10.4%) View all Lupron Depot side effects
Drug Class
Gonadotropin releasing hormones Hormones/antineoplastics	Contraceptives Progestins	Gonadotropin releasing hormones Hormones/antineoplastics
Generic Availability
No lower cost generic approved	Lower cost generic	No lower cost generic approved
Pricing and Coupons * Prices are without insurance
We could not find an exact match for this medicine. Try searching the Price Guide directly.	We could not find an exact match for this medicine. Try searching the Price Guide directly.	We could not find an exact match for this medicine. Try searching the Price Guide directly.
Get free Discount Card	Get free Discount Card	Get free Discount Card

Dosage Forms
Subcutaneous implant	Oral tablet	N/A
Brand Names
Other goserelin brands include: Zoladex 3-Month	Affodel, Camila, Deblitane, Emzahh, Errin, Gallifrey, Heather, Incassia, Jencycla, Lyleq, Lyza, Nor-QD, Norlyda, Norlyroc, Orquidea, Sharobel, Tulana View more	Other leuprolide brands include: Camcevi, Eligard, Fensolvi, Lupron, Lupron Depot-PED, Lutrate Depot
Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value.
4.2 hours	10 hours	4.25 hours
CSA Schedule ¹ View glossary of CSA terms
N Not a controlled drug Is not subject to the Controlled Substances Act.	N Not a controlled drug Is not subject to the Controlled Substances Act.	N Not a controlled drug Is not subject to the Controlled Substances Act.
Pregnancy Category
X Category X Not for use in pregnancy See the full pregnancy warnings document.	X Category X Not for use in pregnancy See the full pregnancy warnings document.	X Category X Not for use in pregnancy See the full pregnancy warnings document.
Drug Interactions
A total of 284 drugs are known to interact with Zoladex: 63 major drug interactions (166 brand and generic names) 220 moderate drug interactions (860 brand and generic names) 1 minor drug interactions (2 brand and generic names)	A total of 262 drugs are known to interact with Norethindrone: 53 major drug interactions (144 brand and generic names) 195 moderate drug interactions (622 brand and generic names) 14 minor drug interactions (67 brand and generic names)	A total of 282 drugs are known to interact with Lupron Depot: 62 major drug interactions (164 brand and generic names) 219 moderate drug interactions (858 brand and generic names) 1 minor drug interactions (2 brand and generic names)
Alcohol/Food/Lifestyle Interactions
No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider.	Grapefruit juice may increase the blood levels of certain medications such as norethindrone. You... View more	No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider.
Disease Interactions
Bone mineral density CV disease Hyperglycemia QTc interval prolongation	Abnormal genital bleeding Hepatic neoplasms Breast malignancy Liver disease Thromboembolism Depression Fluid retention Glucose intolerance Retinal thrombosis Thyroid function tests Hyperlipidemia Weight gain	Cardiovascular disease Diabetes QT interval prolongation Bone mineral density Seizures
First Approval Date
December 29, 1989	April 21, 1982	January 26, 1989
WADA Class View classifications
S2 - Peptide Hormones, Growth Factors and Related Substances	N/A	N/A
More Information
Side effects Drug interactions Dosage Pregnancy warnings Drug images Support group En español	Side effects Drug interactions Dosage Pricing and coupons Pregnancy warnings Breastfeeding warnings Drug images Support group En español	Side effects Drug interactions Dosage Pricing and coupons Pregnancy warnings Drug images Support group En español
Patient Resources
Zoladex uses	Norethindrone uses	Lupron Depot uses
Professional Resources
Prescribing information	Monograph (AHFS) Prescribing information	Prescribing information
Related Treatment Guide
Prostate Cancer Breast Cancer - Palliative Endometriosis Bleeding Disorder	Abnormal Uterine Bleeding Endometriosis Amenorrhea Gender Affirming Hormone Therapy Birth Control	Prostate Cancer Endometriosis Uterine Fibroids

¹ The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

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