Skelaxin Alternatives Compared
| Skelaxin | Cyclobenzaprine | Tizanidine |
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| Skelaxin (metaxalone) | Cyclobenzaprine | Tizanidine |
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Prescription only
Prescribed for Muscle Spasm. Skelaxin may also be used for purposes not listed in this medication guide. |
Prescription only
Cyclobenzaprine is a muscle relaxant that may be used short-term to treat muscle spasms caused by musculoskeletal conditions, in addition to rest and physical therapy. Sedation is a common side... View more |
Prescription only
Tizanidine may be used to reduce muscle spasms but common side effects include sleepiness, a drop in blood pressure, and a dry mouth. The dosage of tizanidine should be tailored to each person and... View more |
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| More about Skelaxin (metaxalone) | More about Cyclobenzaprine | More about Tizanidine | ||||||||||||||||
| Ratings & Reviews | ||||||||||||||||||
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Skelaxin has an average rating of 7.8 out of 10 from a total of 85 ratings on Drugs.com. 67% of reviewers reported a positive effect, while 11% reported a negative effect. |
Cyclobenzaprine has an average rating of 6.0 out of 10 from a total of 615 ratings on Drugs.com. 47% of reviewers reported a positive effect, while 30% reported a negative effect. |
Tizanidine has an average rating of 6.2 out of 10 from a total of 376 ratings on Drugs.com. 48% of reviewers reported a positive effect, while 29% reported a negative effect. |
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| Side Effects | ||||||||||||||||||
| Generic Availability | ||||||||||||||||||
| Lower cost generic approved |
Lower cost generic |
Lower cost generic |
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| Pricing and Coupons * Prices are without insurance | ||||||||||||||||||
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We could not find an exact match for this medicine. Try searching the Price Guide directly. |
View all Cyclobenzaprine prices |
View all Tizanidine prices |
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| Dosage Forms Available | ||||||||||||||||||
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| Brand Names | ||||||||||||||||||
| Other metaxalone brands include: Metaxall | Amrix, Comfort Pac with Cyclobenzaprine | Zanaflex | ||||||||||||||||
| Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value. | ||||||||||||||||||
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3 hours |
72 hours |
2.5 hours |
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| CSA Schedule ** View glossary of terms | ||||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | ||||||||||||||||||
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Category N
Not classified
See the full pregnancy warnings document. |
Category B
No proven risk in humans
See the full pregnancy warnings document. |
Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
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| Drug Interactions | ||||||||||||||||||
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A total of 316 drugs are known to interact with Skelaxin:
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A total of 444 drugs are known to interact with Cyclobenzaprine:
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A total of 634 drugs are known to interact with Tizanidine:
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| Alcohol/Food/Lifestyle Interactions | ||||||||||||||||||
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| Disease Interactions | ||||||||||||||||||
| First Approval Date | ||||||||||||||||||
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August 13, 1962 |
August 26, 1977 |
November 27, 1996 |
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| WADA Class View World Anti-Doping Agency classifications. | ||||||||||||||||||
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N/A |
N/A |
N/A |
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| More Information | ||||||||||||||||||
| Patient resources | ||||||||||||||||||
| Professional Resources | ||||||||||||||||||
| Related Treatment Guide | ||||||||||||||||||
** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.