Selegiline Alternatives Compared

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Selegiline	Rexulti (brexpiprazole)	Bupropion	Enter another drug to compare

Selegiline

Rexulti (brexpiprazole)

Bupropion

Prescription only

Prescribed for Parkinson's Disease, ADHD, Major Depressive Disorder, Depression. Selegiline may also be used for purposes not listed in this medication guide.

Prescription only

Rexulti is an atypical antipsychotic that may be used to treat adults with schizophrenia or depression, or used to relieve agitation associated with dementia in Alzheimer's disease. Most people... View more

Prescription only

Bupropion may be used in the treatment of depression or as an aid to smoking cessation; however, side effects may include insomnia, neuropsychiatric adverse events, or seizures. It carries a black... View more

More about Selegiline

More about Rexulti (brexpiprazole)

More about Bupropion

Ratings & Reviews

Selegiline has an average rating of 7.8 out of 10 from a total of 68 ratings on Drugs.com. 77% of reviewers reported a positive effect, while 11% reported a negative effect.

Rexulti has an average rating of 6.6 out of 10 from a total of 486 ratings on Drugs.com. 54% of reviewers reported a positive effect, while 25% reported a negative effect.

Bupropion has an average rating of 7.1 out of 10 from a total of 2899 ratings on Drugs.com. 61% of reviewers reported a positive effect, while 20% reported a negative effect.

View all 68 reviews

View all 486 reviews

View all 2899 reviews

Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified.

Insomnia (20.6%)
Irritability (5.9%)
Anger (4.4%)
Anxiety (4.4%)
Nightmares (4.4%)

View all Selegiline side effects

Weight gain (21.6%)
Anxiety (9.1%)
Insomnia (7.6%)
Restlessness (6.4%)
Tiredness (6.0%)
Increased appetite (4.5%)
Drowsiness (4.3%)

View all Rexulti side effects

Anxiety (15.7%)
Insomnia (11.2%)
Headaches (7.0%)
Irritability (6.0%)
Sexual dysfunction (5.9%)
Loss of appetite (5.3%)
Nausea (4.9%)

View all Bupropion side effects

Drug Class

Atypical antipsychotics

Generic Availability

Lower cost generic

Lower cost generic approved

Lower cost generic

Pricing and Coupons * Prices are without insurance

Quantity	30 capsule
Strength	5 mg
Per unit^*	$1.04
Cost^*	$31.32

View all Selegiline prices

Quantity	30 tablet
Strength	0.25 mg
Per unit^*	$53.05
Cost^*	$1,591.63

View all Rexulti prices

Quantity	30 each
Strength	150 mg/24 hours
Per unit^*	$1.41
Cost^*	$42.44

View all Bupropion prices

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Dosage Forms

Oral capsule
Oral tablet

Oral tablet

Oral tablet
Oral tablet, extended release

Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value.

84 hours

91 hours

30 hours

CSA Schedule ¹ View glossary of CSA terms

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Pregnancy Category

Category C Risk cannot be ruled out

See the full pregnancy warnings document.

Summary unavailable.

See the full pregnancy warnings document.

Category C Risk cannot be ruled out

See the full pregnancy warnings document.

Drug Interactions

A total of 517 drugs are known to interact with Selegiline:

129 major drug interactions (621 brand and generic names)
386 moderate drug interactions (1639 brand and generic names)
2 minor drug interactions (4 brand and generic names)

A total of 597 drugs are known to interact with Rexulti:

136 major drug interactions (610 brand and generic names)
459 moderate drug interactions (1710 brand and generic names)
2 minor drug interactions (7 brand and generic names)

A total of 526 drugs are known to interact with Bupropion:

216 major drug interactions (946 brand and generic names)
305 moderate drug interactions (1377 brand and generic names)
5 minor drug interactions (16 brand and generic names)

Alcohol/Food/Lifestyle Interactions

While you are taking selegiline, you must not eat or drink certain foods and beverages that are... View more
Using selegiline together with alcohol may increase side effects such as dizziness, drowsiness... View more

Alcohol can increase the nervous system side effects of brexpiprazole such as dizziness... View more

Using buPROPion with alcohol may increase the risk of uncommon side effects such as seizures... View more

Disease Interactions

First Approval Date

June 05, 1989

July 10, 2015

December 30, 1985

WADA Class View classifications

S6 - Stimulants

N/A

More Information

Patient Resources

Rexulti uses

Bupropion uses

Professional Resources

Prescribing information

¹ The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Selegiline Alternatives Compared

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