Comparing Repatha vs Zetia
| Repatha (evolocumab) | Zetia (ezetimibe) |
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| Repatha (evolocumab) | Zetia (ezetimibe) |
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Prescription only
Repatha is a PCSK9 inhibitor that may be used to reduce LDL-C levels in people with primary hyperlipidemia and HoFH, and also to reduce the risk of cardiovascular events in adults with established... View more |
Prescription only
Zetia may be used to lower cholesterol alone or in combination with a statin or fibrate. It has few reported side effects and few drug interactions. It is effective at lowering intestinal absorption... View more |
Related suggestions High Cholesterol
High Cholesterol, Familial Heterozygous
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| More about Repatha (evolocumab) | More about Zetia (ezetimibe) | ||||||||||||||||
| Ratings & Reviews | |||||||||||||||||
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Repatha has an average rating of 5.3 out of 10 from a total of 687 ratings on Drugs.com. 39% of reviewers reported a positive effect, while 46% reported a negative effect. |
Zetia has an average rating of 4.3 out of 10 from a total of 75 ratings on Drugs.com. 29% of reviewers reported a positive effect, while 57% reported a negative effect. |
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| Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified. | |||||||||||||||||
View all Repatha side effects |
View all Zetia side effects |
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| Drug Class | |||||||||||||||||
| Generic Availability | |||||||||||||||||
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N/A |
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| Pricing and Coupons * Prices are without insurance | |||||||||||||||||
View all Repatha prices |
View all Zetia prices |
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| Dosage Forms | |||||||||||||||||
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| Brand Names | |||||||||||||||||
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N/A |
N/A |
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| Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value. | |||||||||||||||||
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408 hours |
22 hours |
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| CSA Schedule 1 View glossary of CSA terms | |||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | |||||||||||||||||
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Summary unavailable. See the full pregnancy warnings document. |
Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
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| Drug Interactions | |||||||||||||||||
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A total of 2 drugs are known to interact with Repatha:
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A total of 67 drugs are known to interact with Zetia:
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| Alcohol/Food/Lifestyle Interactions | |||||||||||||||||
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No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
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| Disease Interactions | |||||||||||||||||
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No known disease interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
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| First Approval Date | |||||||||||||||||
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August 27, 2015 |
October 25, 2002 |
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| WADA Class View classifications | |||||||||||||||||
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N/A |
N/A |
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| More Information | |||||||||||||||||
| Patient Resources | |||||||||||||||||
| Professional Resources | |||||||||||||||||
| Related Treatment Guide | |||||||||||||||||
1 The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.