Comparing Primidone vs Topiramate

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Primidone	Topiramate	Enter another drug to compare

Primidone

Topiramate

Prescription only

Prescribed for Benign Essential Tremor, Seizures, Epilepsy. Primidone may also be used for purposes not listed in this medication guide.

Prescription only

Topiramate may be prescribed either alone or in combination with other medications for the treatment of certain types of epilepsy, or it may be given for the prevention of migraines. Drowsiness is a... View more

More about Primidone

More about Topiramate

Ratings & Reviews

Primidone has an average rating of 6.0 out of 10 from a total of 109 ratings on Drugs.com. 44% of reviewers reported a positive effect, while 28% reported a negative effect.

Topiramate has an average rating of 6.3 out of 10 from a total of 1332 ratings on Drugs.com. 51% of reviewers reported a positive effect, while 28% reported a negative effect.

View all 109 reviews

View all 1332 reviews

Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified.

Dizziness (14.7%)
Tremors (11.0%)
Drowsiness (7.3%)
Nausea (7.3%)
Tiredness (7.3%)
Disorientation (4.6%)
Brain fog (3.7%)

View all Primidone side effects

Tingling (15.6%)
Memory loss (12.7%)
Weight loss (11.5%)
Brain fog (10.1%)
Loss of appetite (7.9%)
Depression (6.6%)
Dizziness (6.4%)

View all Topiramate side effects

Drug Class

Barbiturate anticonvulsants

Carbonic anhydrase inhibitor anticonvulsants

Generic Availability

Lower cost generic

Pricing and Coupons * Prices are without insurance

Quantity	100 each
Strength	50 mg
Per unit^*	$0.25
Cost^*	$24.57

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Quantity	7 tablet
Strength	50 mg
Per unit^*	$2.36
Cost^*	$16.55

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Dosage Forms

Oral tablet

Oral capsule
Oral capsule, extended release
Oral tablet

Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value.

12 hours

56 hours

CSA Schedule ¹ View glossary of CSA terms

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Pregnancy Category

Category N Not classified

See the full pregnancy warnings document.

Category D Positive evidence of risk

See the full pregnancy warnings document.

Drug Interactions

A total of 677 drugs are known to interact with Primidone:

235 major drug interactions (691 brand and generic names)
415 moderate drug interactions (2749 brand and generic names)
27 minor drug interactions (100 brand and generic names)

A total of 291 drugs are known to interact with Topiramate:

108 major drug interactions (654 brand and generic names)
180 moderate drug interactions (721 brand and generic names)
3 minor drug interactions (13 brand and generic names)

Alcohol/Food/Lifestyle Interactions

Ask your doctor before using primidone together with alcohol, this can add to dizziness, drowsiness... View more

Ask your doctor before using alcohol together with topiramate. This can cause excessive sleep... View more

Disease Interactions

First Approval Date

March 08, 1954

December 24, 1996

WADA Class View classifications

N/A

More Information

Patient Resources

Topiramate uses

Professional Resources

¹ The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Comparing Primidone vs Topiramate

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