Comparing Paroxetine vs Sertraline
| Paroxetine | Sertraline |
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| Paroxetine | Sertraline |
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Prescription only
Paroxetine may be used in the treatment of depression or anxiety disorders. Common side effects include headaches and nausea. Taking paroxetine with other medications such as tramadol that also... View more |
Prescription only
Sertraline is an effective antidepressant with less potential for drowsiness than other antidepressants. Headaches, nausea, diarrhea, weight loss, insomnia, tremors, and sexual dysfunction are the... View more |
Related suggestions Depression
Major Depressive Disorder
Anxiety and Stress
Generalized Anxiety Disorder
Popular comparisons
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| More about Paroxetine | More about Sertraline | ||||||||||||||||
| Ratings & Reviews | |||||||||||||||||
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Paroxetine has an average rating of 7.1 out of 10 from a total of 1550 ratings on Drugs.com. 63% of reviewers reported a positive effect, while 19% reported a negative effect. |
Sertraline has an average rating of 7.3 out of 10 from a total of 4563 ratings on Drugs.com. 64% of reviewers reported a positive effect, while 18% reported a negative effect. |
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| Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified. | |||||||||||||||||
View all Paroxetine side effects |
View all Sertraline side effects |
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| Drug Class | |||||||||||||||||
| Generic Availability | |||||||||||||||||
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Lower cost generic |
Lower cost generic |
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| Pricing and Coupons * Prices are without insurance | |||||||||||||||||
View all Paroxetine prices |
View all Sertraline prices |
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| Dosage Forms | |||||||||||||||||
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| Brand Names | |||||||||||||||||
| Brisdelle, Paxil, Paxil CR | Zoloft | ||||||||||||||||
| Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value. | |||||||||||||||||
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21 hours |
66 hours |
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| CSA Schedule 1 View glossary of CSA terms | |||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | |||||||||||||||||
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Category D
Positive evidence of risk
Excluding Brisdelle
Category X
Not for use in pregnancy
Brisdelle See the full pregnancy warnings document. |
Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
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| Drug Interactions | |||||||||||||||||
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A total of 509 drugs are known to interact with Paroxetine:
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A total of 673 drugs are known to interact with Sertraline:
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| Alcohol/Food/Lifestyle Interactions | |||||||||||||||||
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| Disease Interactions | |||||||||||||||||
| First Approval Date | |||||||||||||||||
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December 29, 1992 |
December 30, 1991 |
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| WADA Class View classifications | |||||||||||||||||
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N/A |
N/A |
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| More Information | |||||||||||||||||
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| Related Treatment Guide | |||||||||||||||||
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1 The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.