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Mefloquine Alternatives Compared

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Mefloquine Malarone (atovaquone / proguanil) Doxycycline
View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Mefloquine Malarone (atovaquone / proguanil) Doxycycline
Prescription only

Prescribed for Malaria, Malaria Prevention. Mefloquine may also be used for purposes not listed in this medication guide.

Prescription only

Prescribed for Malaria Prevention, Malaria. Malarone may also be used for purposes not listed in this medication guide.

Prescription only

Doxycycline is an effective antibiotic that treats a wide range of infections. However, it is not usually recommended for children aged less than eight or pregnant women in the last half of their... View more

More about Mefloquine More about Malarone (atovaquone / proguanil) More about Doxycycline
Ratings & Reviews

Mefloquine has an average rating of 4.2 out of 10 from a total of 28 ratings on Drugs.com. 32% of reviewers reported a positive effect, while 57% reported a negative effect.

Malarone has an average rating of 5.5 out of 10 from a total of 45 ratings on Drugs.com. 44% of reviewers reported a positive effect, while 40% reported a negative effect.

Doxycycline has an average rating of 6.4 out of 10 from a total of 1635 ratings on Drugs.com. 50% of reviewers reported a positive effect, while 27% reported a negative effect.

View all 28 reviews

View all 45 reviews

View all 1635 reviews

Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified.

View all Mefloquine side effects

View all Malarone side effects

View all Doxycycline side effects
Drug Class
Generic Availability

Lower cost generic

Lower cost generic approved

Lower cost generic
Pricing and Coupons * Prices are without insurance
Quantity 25 tablet
Strength 250 mg
Per unit* $7.81
Cost* $195.32

View all Mefloquine prices

Quantity 24 tablet
Strength 250 mg-100 mg
Per unit* $7.75
Cost* $185.93

View all Malarone prices

Quantity 2 tablet
Strength hyclate 100 mg
Per unit* $6.62
Cost* $13.23

View all Doxycycline prices

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Dosage Forms
  • Oral tablet
  • Oral tablet
  • Injectable powder for injection
  • Oral capsule
  • Oral delayed release capsule
  • Oral delayed release tablet
  • Oral powder for reconstitution
  • Oral tablet
Brand Names

N/A

 Other atovaquone / proguanil brands include: Malarone Pediatric Acticlate, Adoxa, Adoxa CK, Adoxa Pak, Adoxa TT, Alodox, Avidoxy, Doryx, Doryx MPC, Doxy 100, Doxy 200, Doxy-Caps, Doxy-D, LymePak, Mondoxyne NL, Monodox, Morgidox, Okebo, Oracea, Oraxyl, Targadox, Uracil, Vibramycin View more
Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value.

528 hours

60.5 hours

23 hours
CSA Schedule 1 View glossary of CSA terms
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
Pregnancy Category
B
Category B No proven risk in humans

See the full pregnancy warnings document.
C
Category C Risk cannot be ruled out

See the full pregnancy warnings document.
D
Category D Positive evidence of risk

See the full pregnancy warnings document.
Drug Interactions

A total of 423 drugs are known to interact with Mefloquine:

  • 87 major drug interactions (271 brand and generic names)
  • 326 moderate drug interactions (1181 brand and generic names)
  • 10 minor drug interactions (37 brand and generic names)

A total of 122 drugs are known to interact with Malarone:

  • 13 major drug interactions (27 brand and generic names)
  • 102 moderate drug interactions (578 brand and generic names)
  • 7 minor drug interactions (21 brand and generic names)

A total of 223 drugs are known to interact with Doxycycline:

  • 22 major drug interactions (60 brand and generic names)
  • 196 moderate drug interactions (2214 brand and generic names)
  • 5 minor drug interactions (21 brand and generic names)
Alcohol/Food/Lifestyle Interactions
  • Food can enhance the levels of mefloquine in your body. Take mefloquine immediately after a meal... View more
  • Food significantly enhances the absorption of atovaquone. You should take each dose of atovaquone... View more

No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider.
Disease Interactions
First Approval Date

May 02, 1989

July 14, 2000

December 05, 1967
WADA Class View classifications

N/A

N/A

N/A
More Information
Patient Resources
Professional Resources
Related Treatment Guide

1 The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

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