Comparing Losartan vs Simvastatin

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
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Losartan

Simvastatin

Prescription only

Losartan works on a hormone called angiotensin II to lower blood pressure and may also improve kidney function in some people. People being initiated on losartan should be adequately rehydrated and... View more

Prescription only

Simvastatin is effective at lowering cholesterol; however, it may cause muscle pain, particularly at higher dosages. Should not be used by people with active liver disease or in women planning a... View more

More about Losartan

More about Simvastatin

Ratings & Reviews

Losartan has an average rating of 4.5 out of 10 from a total of 578 ratings on Drugs.com. 26% of reviewers reported a positive effect, while 48% reported a negative effect.

Simvastatin has an average rating of 4.8 out of 10 from a total of 131 ratings on Drugs.com. 30% of reviewers reported a positive effect, while 48% reported a negative effect.

View all 578 reviews

View all 131 reviews

Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified.

Dizziness (14.9%)
Anxiety (14.7%)
Tiredness (12.6%)
Headaches (12.1%)
Cough (11.9%)
Pain (10.9%)
Insomnia (8.3%)

View all Losartan side effects

Insomnia (11.5%)
Pain (11.5%)
Weakness (9.2%)
Cramps (8.4%)
Muscle pain (8.4%)
Tiredness (7.6%)
Headaches (6.9%)

View all Simvastatin side effects

Drug Class

Angiotensin receptor blockers

Statins

Generic Availability

Lower cost generic

Pricing and Coupons * Prices are without insurance

Quantity	50 each
Strength	50 mg
Per unit^*	$0.64
Cost^*	$32.05

View all Losartan prices

Quantity	100 each
Strength	40 mg
Per unit^*	$0.25 - $1.53
Cost^*	$24.57 - $152.61

View all Simvastatin prices

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Dosage Forms

Oral tablet

Oral tablet

Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value.

4.4 hours

N/A

CSA Schedule ¹ View glossary of CSA terms

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Pregnancy Category

Category D Positive evidence of risk

See the full pregnancy warnings document.

Category X Not for use in pregnancy

See the full pregnancy warnings document.

Drug Interactions

A total of 324 drugs are known to interact with Losartan:

32 major drug interactions (165 brand and generic names)
276 moderate drug interactions (1331 brand and generic names)
16 minor drug interactions (39 brand and generic names)

A total of 333 drugs are known to interact with Simvastatin:

59 major drug interactions (232 brand and generic names)
262 moderate drug interactions (680 brand and generic names)
12 minor drug interactions (59 brand and generic names)

Alcohol/Food/Lifestyle Interactions

If you are taking losartan you should avoid potassium-containing salt substitutes or... View more
Losartan and alcohol may have additive effects in lowering your blood pressure. You may experience... View more

Grapefruit juice can significantly increase the blood levels of simvastatin. This can increase the... View more
Simvastatin may cause liver problems and using it with substantial quantities of alcohol may... View more

Disease Interactions

First Approval Date

April 14, 1995

December 23, 1991

WADA Class View classifications

N/A

More Information

Patient Resources

Losartan uses

Simvastatin uses

Professional Resources

¹ The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Comparing Losartan vs Simvastatin

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