Skip to main content

Lidocaine Alternatives Compared

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Lidocaine Propofol Fentanyl
View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Lidocaine Propofol Fentanyl
Prescription only

Lidocaine is used as a local or regional anesthetic to prevent pain signals from being transmitted to the brain during surgical, dental, and other procedures. Lidocaine antiarrhythmic is used in the... View more

Prescription only

Prescribed for Anesthesia. Propofol may also be used for purposes not listed in this medication guide.

Prescription only

Fentanyl is a very potent pain-relieving medicine. It is not recommended for people who have never been prescribed opioid-type pain relief before, and deaths have been reported from improper dosing... View more

More about Lidocaine More about Propofol More about Fentanyl
Ratings & Reviews

Lidocaine has an average rating of 5.3 out of 10 from a total of 21 ratings on Drugs.com. 43% of reviewers reported a positive effect, while 48% reported a negative effect.

Propofol has an average rating of 7.5 out of 10 from a total of 414 ratings on Drugs.com. 68% of reviewers reported a positive effect, while 21% reported a negative effect.

Fentanyl has an average rating of 7.8 out of 10 from a total of 432 ratings on Drugs.com. 72% of reviewers reported a positive effect, while 11% reported a negative effect.

View all 21 reviews

View all 414 reviews

View all 432 reviews

Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified.

View all Lidocaine side effects

View all Propofol side effects

View all Fentanyl side effects
Drug Class
Generic Availability

Lower cost generic

Lower cost generic

Lower cost generic
Pricing and Coupons * Prices are without insurance
Quantity 20 mL
Strength 1% preservative-free
Per unit* $0.70 - $0.78
Cost* $13.93 - $15.59

View all Lidocaine prices

Quantity 200 mL
Strength 10 mg/mL
Per unit* $0.14 - $0.30
Cost* $28.31 - $60.40

View all Propofol prices

Quantity 10 mL
Strength 50 mcg/mL
Per unit* $2.86
Cost* $28.56

View all Fentanyl prices

Get free Discount Card

Get free Discount Card

Get free Discount Card

Dosage Forms
  • Injectable solution
  • Intravenous solution
  • Intravenous emulsion
  • Buccal tablet
  • Injectable solution
  • Intravenous solution
  • Oral transmucosal lozenge
  • Transdermal film, extended release
Brand Names
Anestacaine, DentiPatch, Dilocaine, Xylocaine HCl, Xylocaine-MPF Diprivan, Propoven Actiq, Duragesic, Fentanyl Transdermal System, Fentora, Lazanda, Subsys
Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value.

2 hours

4 hours

8.7 hours
CSA Schedule 1 View glossary of CSA terms
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
2
High potential for abuse

Has a high potential for abuse. Has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions. Abuse may lead to severe psychological or physical dependence.
Pregnancy Category
B
Category B No proven risk in humans

See the full pregnancy warnings document.
B
Category B No proven risk in humans

See the full pregnancy warnings document.
C
Category C Risk cannot be ruled out

See the full pregnancy warnings document.
Drug Interactions

A total of 555 drugs are known to interact with Lidocaine:

  • 37 major drug interactions (146 brand and generic names)
  • 413 moderate drug interactions (2124 brand and generic names)
  • 105 minor drug interactions (419 brand and generic names)

A total of 363 drugs are known to interact with Propofol:

  • 19 major drug interactions (55 brand and generic names)
  • 338 moderate drug interactions (1349 brand and generic names)
  • 6 minor drug interactions (52 brand and generic names)

A total of 633 drugs are known to interact with Fentanyl:

  • 260 major drug interactions (975 brand and generic names)
  • 369 moderate drug interactions (1454 brand and generic names)
  • 4 minor drug interactions (16 brand and generic names)
Alcohol/Food/Lifestyle Interactions
  • Grapefruit juice may increase the blood levels of lidocaine, which may increase the risk of side... View more
  • Alcohol can increase the nervous system side effects of propofol such as dizziness, drowsiness, and... View more
  • Do not use alcohol or medications that contain alcohol while you are receiving treatment with... View more
Disease Interactions
First Approval Date

N/A

October 02, 1989

February 19, 1968
WADA Class View classifications

N/A

N/A
More Information
Patient Resources
Professional Resources
Related Treatment Guide

1 The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Compare Drugs

To view a report comparing 3 (or more) medications, please sign in or create an account.

Create an account Sign In