Comparing Lamotrigine vs Amitriptyline
| Lamotrigine | Amitriptyline |
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| Lamotrigine | Amitriptyline |
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Prescription only
Lamotrigine may be used to decrease the frequency and severity of seizures in some types of epilepsy and also to stabilize mood in bipolar disorder. Rarely, lamotrigine may cause a potentially fatal... View more |
Prescription only
Amitriptyline is an effective antidepressant but it may cause drowsiness initially and a withdrawal syndrome with abrupt discontinuation. It may be used off-label to treat other conditions such as... View more |
Related suggestions Depression
Migraine Prevention (Migraine Prophylaxis)
Post Traumatic Stress Disorder
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| More about Lamotrigine | More about Amitriptyline | ||||||||||||||||
| Ratings & Reviews | |||||||||||||||||
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Lamotrigine has an average rating of 7.8 out of 10 from a total of 1835 ratings on Drugs.com. 73% of reviewers reported a positive effect, while 15% reported a negative effect. |
Amitriptyline has an average rating of 7.5 out of 10 from a total of 1804 ratings on Drugs.com. 68% of reviewers reported a positive effect, while 16% reported a negative effect. |
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| Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified. | |||||||||||||||||
View all Lamotrigine side effects |
View all Amitriptyline side effects |
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| Drug Class | |||||||||||||||||
| Generic Availability | |||||||||||||||||
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Lower cost generic |
Lower cost generic |
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| Pricing and Coupons * Prices are without insurance | |||||||||||||||||
View all Lamotrigine prices |
View all Amitriptyline prices |
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| Dosage Forms | |||||||||||||||||
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| Brand Names | |||||||||||||||||
| Lamictal, Lamictal CD, Lamictal ODT, Lamictal XR, Subvenite |
N/A |
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| Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value. | |||||||||||||||||
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25.7 hours |
16 hours |
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| CSA Schedule 1 View glossary of CSA terms | |||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | |||||||||||||||||
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Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
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| Drug Interactions | |||||||||||||||||
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A total of 286 drugs are known to interact with Lamotrigine:
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A total of 713 drugs are known to interact with Amitriptyline:
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| Alcohol/Food/Lifestyle Interactions | |||||||||||||||||
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| Disease Interactions | |||||||||||||||||
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| First Approval Date | |||||||||||||||||
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December 27, 1994 |
April 07, 1961 |
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| WADA Class View classifications | |||||||||||||||||
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N/A |
N/A |
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| More Information | |||||||||||||||||
| Patient Resources | |||||||||||||||||
| Professional Resources | |||||||||||||||||
| Related Treatment Guide | |||||||||||||||||
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1 The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.