Comparing Lamotrigine vs Amitriptyline
| Lamotrigine | Amitriptyline |
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| Lamotrigine | Amitriptyline |
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Prescription only
Lamotrigine may be used to decrease the frequency and severity of seizures in some types of epilepsy and also to stabilize mood in bipolar disorder. Rarely, lamotrigine may cause a potentially fatal... View more |
Prescription only
Amitriptyline is an effective antidepressant but it may cause drowsiness initially and a withdrawal syndrome with abrupt discontinuation. It may be used off-label to treat other conditions such as... View more |
Related suggestions Depression
Migraine Prevention (Migraine Prophylaxis)
Post Traumatic Stress Disorder
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| More about Lamotrigine | More about Amitriptyline | ||||||||||||||||
| Ratings & Reviews | |||||||||||||||||
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Lamotrigine has an average rating of 7.8 out of 10 from a total of 1806 ratings on Drugs.com. 74% of reviewers reported a positive effect, while 15% reported a negative effect. |
Amitriptyline has an average rating of 7.6 out of 10 from a total of 1785 ratings on Drugs.com. 69% of reviewers reported a positive effect, while 16% reported a negative effect. |
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| Drug Class | |||||||||||||||||
| Side Effects | |||||||||||||||||
| Generic Availability | |||||||||||||||||
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Lower cost generic |
Lower cost generic |
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| Pricing and Coupons * Prices are without insurance | |||||||||||||||||
View all Lamotrigine prices |
View all Amitriptyline prices |
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| Dosage Forms Available | |||||||||||||||||
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| Brand Names | |||||||||||||||||
| Lamictal, Lamictal CD, Lamictal ODT, Lamictal XR, Subvenite |
N/A |
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| Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value. | |||||||||||||||||
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25.7 hours |
16 hours |
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| CSA Schedule ** View glossary of terms | |||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | |||||||||||||||||
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Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
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| Drug Interactions | |||||||||||||||||
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A total of 286 drugs are known to interact with Lamotrigine:
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A total of 709 drugs are known to interact with Amitriptyline:
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| Alcohol/Food/Lifestyle Interactions | |||||||||||||||||
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| Disease Interactions | |||||||||||||||||
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| First Approval Date | |||||||||||||||||
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December 27, 1994 |
April 07, 1961 |
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| WADA Class View World Anti-Doping Agency classifications. | |||||||||||||||||
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N/A |
N/A |
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| More Information | |||||||||||||||||
| Patient resources | |||||||||||||||||
| Professional Resources | |||||||||||||||||
| Related Treatment Guide | |||||||||||||||||
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** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.