Comparing Estradiol Topical vs Osphena
| Estradiol topical | Osphena (ospemifene) |
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| Estradiol topical | Osphena (ospemifene) |
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Prescription only
Prescribed for Atrophic Vaginitis, Atrophic Urethritis, Dyspareunia, Overactive Bladder. Estradiol topical may also be used for purposes not listed in this medication guide. |
Prescription only
Prescribed for Vaginal Dryness, Atrophic Vaginitis, Dyspareunia, Postmenopausal Symptoms, Perimenopausal Symptoms. Osphena may also be used for purposes not listed in this medication guide. |
Related suggestions Atrophic Vaginitis
Dyspareunia
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| More about Estradiol topical | More about Osphena (ospemifene) | ||||||||||||||||
| Ratings & Reviews | |||||||||||||||||
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Estradiol topical has an average rating of 5.1 out of 10 from a total of 487 ratings on Drugs.com. 37% of reviewers reported a positive effect, while 45% reported a negative effect. |
Osphena has an average rating of 5.3 out of 10 from a total of 45 ratings on Drugs.com. 36% of reviewers reported a positive effect, while 40% reported a negative effect. |
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| Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified. | |||||||||||||||||
View all Estradiol topical side effects |
View all Osphena side effects |
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| Drug Class | |||||||||||||||||
| Generic Availability | |||||||||||||||||
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Lower cost generic |
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| Pricing and Coupons * Prices are without insurance | |||||||||||||||||
View all Estradiol topical prices |
View all Osphena prices |
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| Dosage Forms | |||||||||||||||||
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| Brand Names | |||||||||||||||||
| Estrace Vaginal Cream, Estring, Imvexxy, Vagifem, Yuvafem |
N/A |
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| Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value. | |||||||||||||||||
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N/A |
26 hours |
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| CSA Schedule 1 View glossary of CSA terms | |||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | |||||||||||||||||
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Category X
Not for use in pregnancy
See the full pregnancy warnings document. |
Category X
Not for use in pregnancy
See the full pregnancy warnings document. |
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| Drug Interactions | |||||||||||||||||
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A total of 237 drugs are known to interact with Estradiol topical:
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A total of 97 drugs are known to interact with Osphena:
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| Alcohol/Food/Lifestyle Interactions | |||||||||||||||||
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No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
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| Disease Interactions | |||||||||||||||||
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| First Approval Date | |||||||||||||||||
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January 31, 1984 |
February 26, 2013 |
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| WADA Class View classifications | |||||||||||||||||
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N/A |
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| More Information | |||||||||||||||||
| Patient Resources | |||||||||||||||||
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| Related Treatment Guide | |||||||||||||||||
1 The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.