Estradiol / progesterone Alternatives Compared
| Estradiol / progesterone | Progesterone | Clonidine |
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| Estradiol / progesterone | Progesterone | Clonidine |
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Prescription only
Prescribed for Postmenopausal Symptoms, Menopausal Disorders, Perimenopausal Symptoms, Hot Flashes. Estradiol / progesterone may also be used for purposes not listed in this medication guide. |
Prescription and OTC
Progesterone is a hormone that is used to treat conditions associated with ovulation, fertility, menstruation, menopause, or abnormal uterine bleeding. It may be used in gender-affirming therapy to... View more |
Prescription only
Clonidine can be used to lower blood pressure and treat ADHD; however, it causes sedation, and tolerance can develop to its blood pressure-lowering effects. Clonidine should not be stopped suddenly... View more |
Related suggestions Perimenopausal Symptoms
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| More about Estradiol / progesterone | More about Progesterone | More about Clonidine | ||||||||||||||||
| Ratings & Reviews | ||||||||||||||||||
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Estradiol / progesterone has an average rating of 6.1 out of 10 from a total of 45 ratings on Drugs.com. 40% of reviewers reported a positive effect, while 26% reported a negative effect. |
Progesterone has an average rating of 6.5 out of 10 from a total of 77 ratings on Drugs.com. 48% of reviewers reported a positive effect, while 23% reported a negative effect. |
Clonidine has an average rating of 7.2 out of 10 from a total of 765 ratings on Drugs.com. 63% of reviewers reported a positive effect, while 21% reported a negative effect. |
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| Drug Class | ||||||||||||||||||
| Side Effects | ||||||||||||||||||
| Generic Availability | ||||||||||||||||||
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N/A |
Lower cost generic |
Lower cost generic |
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| Pricing and Coupons * Prices are without insurance | ||||||||||||||||||
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We could not find an exact match for this medicine. Try searching the Price Guide directly. |
View all Progesterone prices |
View all Clonidine prices |
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| Dosage Forms Available | ||||||||||||||||||
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N/A |
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| Brand Names | ||||||||||||||||||
| Bijuva | Crinone, Cyclogest, Endometrin, First Progesterone MC10, First Progesterone MC5, Gestone, Milprosa, Prometrium | Catapres, Catapres-TTS, Clonidine ER, Duraclon, Kapvay, Nexiclon XR, Onyda XR | ||||||||||||||||
| Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value. | ||||||||||||||||||
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26.47 hours |
1 hour |
15 hours |
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| CSA Schedule ** View glossary of terms | ||||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | ||||||||||||||||||
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Summary unavailable. See the full pregnancy warnings document. |
Category B
No proven risk in humans
Oral Formulations
Category N
Not classified
Excluding Oral Formulations See the full pregnancy warnings document. |
Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
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| Drug Interactions | ||||||||||||||||||
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A total of 385 drugs are known to interact with Estradiol / progesterone:
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A total of 205 drugs are known to interact with Progesterone:
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A total of 374 drugs are known to interact with Clonidine:
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| Disease Interactions | ||||||||||||||||||
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| First Approval Date | ||||||||||||||||||
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October 28, 2018 |
November 01, 1974 |
September 03, 1974 |
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| WADA Class View World Anti-Doping Agency classifications. | ||||||||||||||||||
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N/A |
N/A |
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| More Information | ||||||||||||||||||
| Patient resources | ||||||||||||||||||
| Professional Resources | ||||||||||||||||||
| Related Treatment Guide | ||||||||||||||||||
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** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.