Estradiol / progesterone Alternatives Compared
| Estradiol / progesterone | Progesterone | Clonidine |
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| Estradiol / progesterone | Progesterone | Clonidine |
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Prescription only
Prescribed for Postmenopausal Symptoms, Perimenopausal Symptoms, Menopausal Disorders, Hot Flashes. Estradiol / progesterone may also be used for purposes not listed in this medication guide. |
Prescription and OTC
Progesterone is a hormone that is used to treat conditions associated with ovulation, fertility, menstruation, menopause, or abnormal uterine bleeding. It may be used in gender-affirming therapy to... View more |
Prescription only
Clonidine can be used to lower blood pressure and extended-release forms are used to treat ADHD; however, it causes sedation, and tolerance can develop to its blood pressure-lowering effects... View more |
Related suggestions Perimenopausal Symptoms
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| More about Estradiol / progesterone | More about Progesterone | More about Clonidine | ||||||||||||||||
| Ratings & Reviews | ||||||||||||||||||
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Estradiol / progesterone has an average rating of 6.0 out of 10 from a total of 46 ratings on Drugs.com. 39% of reviewers reported a positive effect, while 26% reported a negative effect. |
Progesterone has an average rating of 6.5 out of 10 from a total of 78 ratings on Drugs.com. 49% of reviewers reported a positive effect, while 21% reported a negative effect. |
Clonidine has an average rating of 7.1 out of 10 from a total of 774 ratings on Drugs.com. 61% of reviewers reported a positive effect, while 21% reported a negative effect. |
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| Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified. | ||||||||||||||||||
View all Progesterone side effects |
View all Clonidine side effects |
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| Drug Class | ||||||||||||||||||
| Generic Availability | ||||||||||||||||||
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N/A |
Lower cost generic |
Lower cost generic |
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| Pricing and Coupons * Prices are without insurance | ||||||||||||||||||
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We could not find an exact match for this medicine. Try searching the Price Guide directly. |
View all Progesterone prices |
View all Clonidine prices |
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| Dosage Forms | ||||||||||||||||||
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N/A |
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| Brand Names | ||||||||||||||||||
| Bijuva | Crinone, Cyclogest, Endometrin, First Progesterone MC10, First Progesterone MC5, Gestone, Milprosa, Prometrium | Catapres, Catapres-TTS, Clonidine ER, Duraclon, Kapvay, Nexiclon XR, Onyda XR | ||||||||||||||||
| Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value. | ||||||||||||||||||
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26.47 hours |
1 hour |
15 hours |
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| CSA Schedule 1 View glossary of CSA terms | ||||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | ||||||||||||||||||
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Summary unavailable. See the full pregnancy warnings document. |
Category B
No proven risk in humans
Oral Formulations
Category N
Not classified
Excluding Oral Formulations See the full pregnancy warnings document. |
Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
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| Drug Interactions | ||||||||||||||||||
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A total of 391 drugs are known to interact with Estradiol / progesterone:
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A total of 211 drugs are known to interact with Progesterone:
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A total of 375 drugs are known to interact with Clonidine:
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| Alcohol/Food/Lifestyle Interactions | ||||||||||||||||||
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| Disease Interactions | ||||||||||||||||||
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| First Approval Date | ||||||||||||||||||
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October 28, 2018 |
November 01, 1974 |
September 03, 1974 |
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| WADA Class View classifications | ||||||||||||||||||
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N/A |
N/A |
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| More Information | ||||||||||||||||||
| Patient Resources | ||||||||||||||||||
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| Related Treatment Guide | ||||||||||||||||||
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1 The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.