Comparing Duloxetine vs Paroxetine
| Duloxetine | Paroxetine |
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| Duloxetine | Paroxetine |
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Prescription only
Duloxetine has antidepressant, anti-anxiety, and pain-relieving properties; however, it may cause a discontinuation syndrome on withdrawal even when tapered. Symptoms may include anxiety, headache... View more |
Prescription only
Paroxetine may be used in the treatment of depression or anxiety disorders. Common side effects include headaches and nausea. Taking paroxetine with other medications such as tramadol that also... View more |
Related suggestions Depression
Major Depressive Disorder
Generalized Anxiety Disorder
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| More about Duloxetine | More about Paroxetine | ||||||||||||||||
| Ratings & Reviews | |||||||||||||||||
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Duloxetine has an average rating of 6.2 out of 10 from a total of 2457 ratings on Drugs.com. 52% of reviewers reported a positive effect, while 31% reported a negative effect. |
Paroxetine has an average rating of 7.1 out of 10 from a total of 1550 ratings on Drugs.com. 63% of reviewers reported a positive effect, while 19% reported a negative effect. |
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| Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified. | |||||||||||||||||
View all Duloxetine side effects |
View all Paroxetine side effects |
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| Drug Class | |||||||||||||||||
| Generic Availability | |||||||||||||||||
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Lower cost generic |
Lower cost generic |
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| Pricing and Coupons * Prices are without insurance | |||||||||||||||||
View all Duloxetine prices |
View all Paroxetine prices |
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| Dosage Forms | |||||||||||||||||
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| Brand Names | |||||||||||||||||
| Cymbalta, Drizalma Sprinkle, Irenka | Brisdelle, Paxil, Paxil CR | ||||||||||||||||
| Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value. | |||||||||||||||||
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17 hours |
21 hours |
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| CSA Schedule 1 View glossary of CSA terms | |||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | |||||||||||||||||
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Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
Category D
Positive evidence of risk
Excluding Brisdelle
Category X
Not for use in pregnancy
Brisdelle See the full pregnancy warnings document. |
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| Drug Interactions | |||||||||||||||||
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A total of 624 drugs are known to interact with Duloxetine:
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A total of 509 drugs are known to interact with Paroxetine:
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| Alcohol/Food/Lifestyle Interactions | |||||||||||||||||
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| Disease Interactions | |||||||||||||||||
| First Approval Date | |||||||||||||||||
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August 03, 2004 |
December 29, 1992 |
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| WADA Class View classifications | |||||||||||||||||
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N/A |
N/A |
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| More Information | |||||||||||||||||
| Patient Resources | |||||||||||||||||
| Professional Resources | |||||||||||||||||
| Related Treatment Guide | |||||||||||||||||
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1 The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.